| Two modes of activation of a single surface antigen gene of Trypanosoma brucei. | |
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MedLine Citation:
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PMID: 6692467 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Several genes for variant antigens in trypanosomes are activated by duplicative translocation to a telomeric expression site. A second--nonduplicative--mode of activation is restricted to telomeric antigen genes. We show here that the single telomeric gene for antigen 221 can be activated in both ways. We also show that gene 221 is split and that the 5' 35 nucleotide sequence, common to all surface antigen mRNAs, is not encoded within 8.5 kb upstream of the 221 coding region. No major rearrangements are observed within 55 kb upstream of the 221 coding region upon nonduplicative activation. Gene inactivation is usually accompanied by deletion of the gene and at least 8.5 kb upstream and may involve conversion by another telomere. These results are not readily explained by a single expression site model. The duplicative gene 221 activation differs from conventional duplicative activation in the extent of the transposed segment, which is larger and may include the entire segment between gene and telomere. |
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Authors:
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A Bernards; T De Lange; P A Michels; A Y Liu; M J Huisman; P Borst |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cell Volume: 36 ISSN: 0092-8674 ISO Abbreviation: Cell Publication Date: 1984 Jan |
Date Detail:
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Created Date: 1984-03-02 Completed Date: 1984-03-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0413066 Medline TA: Cell Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 163-70 Citation Subset: IM |
| Data Bank Information | |
Bank Name/Acc. No.:
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GENBANK/K01290 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigens, Surface / genetics* Base Sequence Chromosome Deletion Gene Conversion Gene Expression Regulation* Glycoproteins / genetics*, immunology Models, Genetic Trypanosoma brucei brucei / genetics*, immunology Variant Surface Glycoproteins, Trypanosoma |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Surface; 0/Glycoproteins; 0/Variant Surface Glycoproteins, Trypanosoma |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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