| Two medical abortion regimens for late first-trimester termination of pregnancy: a prospective randomized trial. | |
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MedLine Citation:
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PMID: 20227549 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Medical abortion regimens based on the use of either misoprostol alone or in association with mifepristone have shown high efficacy and excellent safety profile in early pregnancy abortion. However, no clear recommendation is available for late first-trimester termination of pregnancy. STUDY DESIGN: A prospective randomized controlled trial included 122 women seeking medical abortion at 9 to 12 weeks of gestation. Seventy-three patients were given a fixed protocol of 200 mg of mifepristone followed 48 h later by 400 mcg oral misoprostol (Group 1). The second group of 49 patients was administered 800-mcg intravaginal single-dose misoprostol (Group 2). This study sought to compare safety, efficacy and acceptability of these two nonsurgical abortion regimens. RESULTS: Fifty-nine (80.8%) women in Group 1 had complete abortion vs. 38 (77.4%) women in Group 2 (p=.66). Abdominal pain was observed significantly more often in Group 2 (35/49 (71.4%) vs. 32/73 (43.8%) in Group 1, p<.0001. Medical abortion was equally acceptable among the two groups [37/49 (75.5%) and 55/73 (75.7%), p=.89]. CONCLUSION: For late first-trimester termination, a single 800-mcg vaginal dose of misoprostol seems to be as effective as the mifepristone+misoprostol regimen, with acceptable side effects. |
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Authors:
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Chelly Dalenda; Najar Ines; Boudaya Fathia; Affes Malika; Zouaoui Bechir; Sfar Ezzeddine; Chelly Hela; Channoufi Mohamed Badis |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2010-01-15 |
Journal Detail:
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Title: Contraception Volume: 81 ISSN: 1879-0518 ISO Abbreviation: Contraception Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-15 Completed Date: 2010-06-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0234361 Medline TA: Contraception Country: United States |
Other Details:
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Languages: eng Pagination: 323-7 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department A of Obstetrics and Gynecology, Tunisian Maternity and Neonatology Center, Rabta, Tunis, Tunisia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abdominal Pain
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chemically induced,
drug therapy Abortifacient Agents, Nonsteroidal / administration & dosage*, adverse effects Abortifacient Agents, Steroidal / administration & dosage*, adverse effects Abortion, Induced / adverse effects, methods* Adult Female Humans Mifepristone / administration & dosage*, adverse effects Misoprostol / administration & dosage*, adverse effects Pregnancy Pregnancy Trimester, First / drug effects* Prospective Studies Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Abortifacient Agents, Nonsteroidal; 0/Abortifacient Agents, Steroidal; 59122-46-2/Misoprostol; 84371-65-3/Mifepristone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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