| Two loci, Tmevp2 and Tmevp3, located on the telomeric region of chromosome 10, control the persistence of Theiler's virus in the central nervous system of mice. | |
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MedLine Citation:
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PMID: 10224268 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Theiler's virus persistently infects the white matter of the spinal cord in susceptible strains of mice. This infection is associated with inflammation and primary demyelination and is studied as a model of multiple sclerosis. The H-2D gene is the major gene controlling viral persistence. However, the SJL/J strain is more susceptible than predicted by its H-2(s) haplotype. An (SJL/J x B10. S)F1 x B10.S backcross was analyzed, and one quantitative trait locus (QTL) was located in the telomeric region of chromosome 10 close to the Ifng locus. Another one was tentatively mapped to the telomeric region of chromosome 18, close to the Mbp locus. We now report the study of 14 congenic lines that carry different segments of these two chromosomes. Although the presence of a QTL on chromosome 18 was not confirmed, two loci controlling viral persistence were identified on chromosome 10 and named Tmevp2 and Tmevp3. Furthermore, the Ifng gene was excluded from the regions containing Tmevp2 and Tmevp3. Analysis of the mode of inheritance of Tmevp2 and Tmevp3 identified an effect of sex, with males being more infected than females. |
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Authors:
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F Bihl; M Brahic; J F Bureau |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Genetics Volume: 152 ISSN: 0016-6731 ISO Abbreviation: Genetics Publication Date: 1999 May |
Date Detail:
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Created Date: 1999-07-12 Completed Date: 1999-07-12 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0374636 Medline TA: Genetics Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 385-92 Citation Subset: IM |
Affiliation:
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Unité des Virus Lents (URA CNRS 1930), Institut Pasteur, 75724 Paris Cedex 15, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Cell Line Chromosome Mapping Crosses, Genetic Female Genetic Predisposition to Disease Genotype Male Mice Microsatellite Repeats Phenotype RNA, Viral / analysis Sex Factors Spinal Cord / virology* Telomere / genetics* Theilovirus / genetics* |
| Chemical | |
Reg. No./Substance:
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0/RNA, Viral |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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