Document Detail

Two hybridization events define the population structure of Trypanosoma cruzi.
MedLine Citation:
PMID:  15998728     Owner:  NLM     Status:  MEDLINE    
Genetic variation in Trypanosoma cruzi is likely a key determinant in transmission and pathogenesis of Chagas disease. We have examined nine loci as markers for the extant T. cruzi strains. Four distinct alleles were found for each locus, corresponding to the sequence classes present in the homozygous discrete typing units (DTUs) I, IIa, IIb, and IIc. The alleles in DTUs IIa and IIc showed a spectrum of polymorphism ranging from DTU I-like to DTU IIb-like, in addition to DTU-specific sequence variation. DTUs IId and IIe were indistinguishable, showing DTU homozygosity at one locus and heterozygosity with DTU IIb and IIc allelic sequences at eight loci. Recombination between the DTU IIb and IIc alleles is evidenced from mosaic polymorphisms. These data imply that two discrete hybridization events resulted in the formation of the current DTUs. We propose a model in which a fusion between ancestral DTU I and IIb strains gave rise to a heterozygous hybrid that homogenized its genome to become the homozygous progenitor of DTUs IIa and IIc. The second hybridization between DTU IIb and IIc strains that generated DTUs IId and IIe resulted in extensive heterozygosity with subsequent recombination of parental genotypes.
Scott J Westenberger; Christian Barnabé; David A Campbell; Nancy R Sturm
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.     Date:  2005-07-05
Journal Detail:
Title:  Genetics     Volume:  171     ISSN:  0016-6731     ISO Abbreviation:  Genetics     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-10-26     Completed Date:  2006-06-27     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  0374636     Medline TA:  Genetics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  527-43     Citation Subset:  IM    
Department of Microbiology, Immunology & Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, 90095, USA.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/AY540638;  AY540639;  AY540640;  AY540641;  AY540642;  AY540643;  AY540644;  AY540645;  AY540646;  AY540647;  AY540648;  AY540649;  AY540650;  AY540651;  AY540652;  AY540653;  AY540654;  AY540655;  AY540656;  AY540657;  AY540658;  AY540659;  AY540660;  AY540661;  AY540662;  AY540663;  AY540664;  AY540665;  AY540666;  AY540667;  AY540668;  AY540669;  AY540670;  AY540671;  AY540672;  AY540673;  AY540674;  AY540675;  AY540676;  AY540677;  AY540678;  AY540679;  AY540680;  AY540681;  AY540682;  AY540683;  AY540684;  AY540685;  AY540686;  AY540687;  AY540688;  AY540689;  AY540690;  AY540691;  AY540692;  AY540693;  AY540694;  AY540695;  AY540696;  AY540697;  AY540698;  AY540699;  AY540700;  AY540701;  AY540702;  AY540703;  AY540704;  AY540705;  AY540706;  AY540707;  AY540708;  AY540709;  AY540710;  AY540711;  AY540712;  AY540713;  AY540714;  AY540715;  AY540716;  AY540717;  AY540718;  AY540719;  AY540720;  AY540721;  AY540722;  AY540723;  AY540724;  AY540725;  AY540726;  AY540727;  AY540728;  AY540729;  AY540730;  AY540731;  AY540732;  AY540733;  AY540734;  AY540735;  AY540736;  AY540737;  AY540738;  AY540739;  AY540740;  AY540741;  AY540742;  AY540743;  AY540744;  DQ021887;  DQ021888;  DQ021889;  DQ021890;  DQ021891;  DQ021892;  DQ021893;  DQ021894;  DQ021895;  DQ021896;  DQ021897;  DQ021898;  DQ021899
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MeSH Terms
Base Sequence
Cluster Analysis
Evolution, Molecular*
Genes, Protozoan / genetics
Genetic Variation*
Genetics, Population*
Hybridization, Genetic*
Models, Genetic*
Molecular Sequence Data
Polymorphism, Restriction Fragment Length
Polymorphism, Single Nucleotide / genetics
Sequence Alignment
Sequence Analysis, DNA
Species Specificity
Trypanosoma cruzi / genetics*

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