Document Detail


Two human genes encoding zinc finger proteins, ZNF 12 (KOX 3) and ZNF 26 (KOX 20), map to chromosome 7p22-p21 and 12q24.33, respectively.
MedLine Citation:
PMID:  2026422     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Two members of the human zinc finger Krüppel family, ZNF 12 (KOX 3) and ZNF 26 (KOX 20), have been localized by somatic cell hybrid analysis and in situ chromosomal hybridization. The presence of individual human zinc finger genes in mouse-human hybrid DNAs was correlated with the presence of specific human chromosomes or regions of chromosomes in the corresponding cell hybrids. Analysis of such mouse-human hybrid DNAs allowed the assignment of the ZNF 12 (KOX 3) gene to chromosome region 7p. The ZNF 26 (KOX 20) gene segregated with chromosome region 12q13-qter. The zinc finger genes ZNF 12 (KOX 3) and ZNF 26 (KOX 20) were localized by in situ chromosomal hybridization to human chromosome regions 7p22-21 and 12q24.33, respectively. These genes and the previously mapped ZNF 24 (KOX 17) and ZNF 29 (KOX 26) genes, are found near fragile sites.
Authors:
P Seite; K Huebner; M F Rousseau-Merck; R Berger; H J Thiesen
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Human genetics     Volume:  86     ISSN:  0340-6717     ISO Abbreviation:  Hum. Genet.     Publication Date:  1991 Apr 
Date Detail:
Created Date:  1991-06-10     Completed Date:  1991-06-10     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7613873     Medline TA:  Hum Genet     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  585-90     Citation Subset:  IM    
Affiliation:
INSERM U, 301 Institut de Génétique Moléculaire, Paris, France.
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Chromosome Banding
Chromosome Mapping
Chromosomes, Human, Pair 12*
Chromosomes, Human, Pair 7*
Humans
Hybrid Cells
Mice
Mitosis
Molecular Sequence Data
Multigene Family
Nucleic Acid Hybridization
Zinc Fingers / genetics*
Grant Support
ID/Acronym/Agency:
CA 21124/CA/NCI NIH HHS; CA 25875/CA/NCI NIH HHS

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