Document Detail

Two holes syndrome (THS) is present in more than half of the postnasal drip patients?
MedLine Citation:
PMID:  20450396     Owner:  NLM     Status:  MEDLINE    
CONCLUSION: Posterior fontanelle defects were found in almost half of the patients with postnasal drip and in a negligible number in the cohort of healthy subjects.
OBJECTIVES: The aim of this study was to compare the incidence of fontanelle defects in patients with postnasal drip and in healthy subjects.
MATERIALS: A total of 723 outpatients suffering from postnasal drip as a leading symptom were examined during the last 10 years by means of nasal fiberendoscopy. The authors were searching for defects in the posterior fontanelle region and recirculating mucus. The control group consisted of 312 healthy volunteers with no history of postnasal drip.
RESULTS: The defect in the posterior fontanelle was found in 414 of 723 patients with postnasal drip (57.3%). It was bilateral in 238 of 414 cases (57.5%). The defect in the anterior fontanelle was not found in this cohort at all. The recirculating mucus ring was clearly identified in 107 of 414 patients (25.8%). The defect in the posterior fontanelle was found in only 7 of 312 healthy volunteers (2.2%) (p < 0.01).
Ranko Mladina; Neven Skitarelić; Manuele Casale
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Acta oto-laryngologica     Volume:  130     ISSN:  1651-2251     ISO Abbreviation:  Acta Otolaryngol.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-14     Completed Date:  2011-01-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370354     Medline TA:  Acta Otolaryngol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1274-7     Citation Subset:  IM    
Department of Otorhinolaryngology and Head and Neck Surgery, Clinical Hospital Centre Zagreb, Croatia.
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MeSH Terms
Aged, 80 and over
Case-Control Studies
Chronic Disease
Cohort Studies
Cranial Fontanelles / abnormalities*
Middle Aged
Nasal Mucosa / secretion
Rhinitis / epidemiology*,  physiopathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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