| Two-hit hypothesis and multiple organ dysfunction syndrome. | |
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MedLine Citation:
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PMID: 18709037 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A severe insult in the form of infection or trauma primes the host immune system so that a subsequent, relatively trivial insult produces a markedly exaggerated host immune response, which can lead to multiple organ dysfunction syndrome (MODS) and death. This forms the basis of the "two-hit hypothesis" (THH), which is being increasingly recognised as an important cause of morbidity and mortality following severe injury and sepsis, particularly in intensive care settings. Appreciation of the impact of repeated insults and pathophysiology of MODS is vital in the prevention of this serious complication. We describe a case which illustrates the concept of THH and MODS and present a review of literature on this subject. |
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Authors:
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I Butt; B M Shrestha |
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Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: JNMA; journal of the Nepal Medical Association Volume: 47 ISSN: 0028-2715 ISO Abbreviation: JNMA J Nepal Med Assoc Publication Date: 2008 Apr-Jun |
Date Detail:
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Created Date: 2008-08-18 Completed Date: 2009-01-29 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0045233 Medline TA: JNMA J Nepal Med Assoc Country: Nepal |
Other Details:
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Languages: eng Pagination: 82-5 Citation Subset: IM |
Affiliation:
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Sheffield Kidney Institute, Sheffield, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged, 80 and over Fatal Outcome Female Humans Laparotomy / adverse effects* Multiple Organ Failure / etiology* Reoperation / adverse effects |
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