Document Detail


Two genes encode distinct glutamate decarboxylases.
MedLine Citation:
PMID:  2069816     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
gamma-Aminobutyric acid (GABA) is the most widely distributed known inhibitory neurotransmitter in the vertebrate brain. GABA also serves regulatory and trophic roles in several other organs, including the pancreas. The brain contains two forms of the GABA synthetic enzyme glutamate decarboxylase (GAD), which differ in molecular size, amino acid sequence, antigenicity, cellular and subcellular location, and interaction with the GAD cofactor pyridoxal phosphate. These forms, GAD65 and GAD67, derive from two genes. The distinctive properties of the two GADs provide a substrate for understanding not only the multiple roles of GABA in the nervous system, but also the autoimmune response to GAD in insulin-dependent diabetes mellitus.
Authors:
M G Erlander; N J Tillakaratne; S Feldblum; N Patel; A J Tobin
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neuron     Volume:  7     ISSN:  0896-6273     ISO Abbreviation:  Neuron     Publication Date:  1991 Jul 
Date Detail:
Created Date:  1991-08-22     Completed Date:  1991-08-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8809320     Medline TA:  Neuron     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  91-100     Citation Subset:  IM    
Affiliation:
Neuroscience Program, University of California Los Angeles 90024.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/M67516;  M72422;  S61932;  S61935;  S70258;  S70261;  S70262;  X57453;  X57454;  X57455
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Antigens / immunology
Bacteria / enzymology
Brain / enzymology
Genes*
Glutamate Decarboxylase / genetics*,  immunology,  metabolism
Molecular Sequence Data
Pyridoxal Phosphate / pharmacology
RNA, Messenger / metabolism
Rats
Subcellular Fractions / enzymology
Chemical
Reg. No./Substance:
0/Antigens; 0/RNA, Messenger; 54-47-7/Pyridoxal Phosphate; EC 4.1.1.15/Glutamate Decarboxylase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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