| Two generation reproduction and teratogenicity studies of feeding quinocetone fed to Wistar rats. | |
| | |
MedLine Citation:
|
PMID: 22248866 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
To investigate the reproductive toxicity and teratogenic potential of quinocetone, a growth promoting agent, Wistar rats were fed different diets containing 0, 50, 300 and 1800mg/kg quinocetone or 300mg/kg olaquindox. Groups of 15 males and 30 females (F(0)) were fed through a 10-week prebreed period as well as during mating, gestation, parturition and lactation. At weaning, 12 males and 24 females of F(1) generation weanlings per group were selected randomly as parents for F(2) generation. Selected F(1) weanlings were exposed to the same diet and treatment as their parents. At the highest quinocetone group, body weights in F(0) and F(1) rats, fetal body weight on day 21 after birth and number of viable fetuses in F(0) and F(1) generation significantly decreased. In teratogenicity study, groups of 12 males and 24 females were fed with the same diets through a 12-week prebreed period and matting periods. Pregnant rats were subjected to cesarean section on GD 20 for teratogenic examination. At the highest quinocetone group, body weights and feed efficiency, fetal body lengths, tail lengths, litter weights and number of viable fetuses significantly decreased. The NOAEL for reproduction/development of quinocetone for rats was estimated to be 300mg/kg diet. |
| | |
Authors:
|
Xu Wang; Wei Zhang; Yu-Lian Wang; Awais Ihsan; Meng-Hong Dai; Ling-Li Huang; Dong-Mei Chen; Yan-Fei Tao; Da-Peng Peng; Zhen-Li Liu; Zong-Hui Yuan |
Related Documents
:
|
2637936 - Effect of low-calorie diets on metabolism of man under hypokinesia. 492426 - Effect of low protein diet and surplus of essential amino acids on the serum concentrat... 2512806 - Total-body protein turnover in parenterally fed neonates: effects of energy source stud... 1909086 - A randomized, controlled trial of treatment of alcoholic hepatitis with parenteral nutr... 19679266 - The clinical implications of the chicago study for the management of cardiovascular ris... 2535346 - Influence of zinc and calcium deficiency on the concentrations of calcitonin, parathyro... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-10 |
Journal Detail:
|
Title: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association Volume: - ISSN: 1873-6351 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-1-17 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8207483 Medline TA: Food Chem Toxicol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012. Published by Elsevier Ltd. |
Affiliation:
|
National Reference Laboratory of Veterinary Drug Residues (HZAU)/MOA Key Laboratory for the Detection of Veterinary Drug Residues in Foods, Huazhong Agricultural University, Wuhan, Hubei 430070, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Chemical composition, antiproliferative and antioxidant properties of lipid classes in ordinary and ...
Next Document: High-speed atomic force microscopy coming of age.