Document Detail

Two or four hour [¹⁸F]FMISO-PET in HNSCC. When is the contrast best?
MedLine Citation:
PMID:  21165537     Owner:  NLM     Status:  MEDLINE    
RESULTS: Mean SUVmax in tumours of all examinations was 2.2 (stdev: 0.4, min: 1.3, max: 3.4) after 2 h and 2.4 (stdev: 0.7, min: 1.1, max: 4.4) after 4 h. In the neck musculature the mean SUVmax was 1.5 at both time points and the mean SUVmean decreased from 1.2 after 2 h to 1.1 after 4 h, respectively. These effects resulted in significantly rising contrast ratios from MISO2 to MISO4. The differently defined contrasts revealed significantly higher values for examinations 4 h p.i. (p < 0.002).
CONCLUSION: Data acquisition of [¹⁸F]FMISO should be done 4 h p.i. to gather the optimal contrast, preferably allowing further analysis, e. g. hypoxic sub volume definition for therapy planning.
N Abolmaali; R Haase; A Koch; D Zips; J Steinbach; M Baumann; J Kotzerke; K Zöphel
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-12-17
Journal Detail:
Title:  Nuklearmedizin. Nuclear medicine     Volume:  50     ISSN:  0029-5566     ISO Abbreviation:  Nuklearmedizin     Publication Date:  2011  
Date Detail:
Created Date:  2011-02-21     Completed Date:  2011-04-12     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  7609387     Medline TA:  Nuklearmedizin     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  22-7     Citation Subset:  IM    
OncoRay-Molecular and Biological Imaging, National Center for Radiation Research in Oncology, Institut und Poliklinik für Radiologische Diagnostik, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
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MeSH Terms
Carcinoma, Small Cell / radionuclide imaging*
Head and Neck Neoplasms / radionuclide imaging*
Image Enhancement / methods*
Middle Aged
Misonidazole / administration & dosage,  analogs & derivatives*,  diagnostic use
Positron-Emission Tomography / methods*
Radiopharmaceuticals / administration & dosage,  diagnostic use
Reproducibility of Results
Sensitivity and Specificity
Time Factors
Reg. No./Substance:
0/Radiopharmaceuticals; 13551-87-6/Misonidazole; 13551-89-8/fluoromisonidazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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