Document Detail

Two or four hour [¹⁸F]FMISO-PET in HNSCC. When is the contrast best?
MedLine Citation:
PMID:  21165537     Owner:  NLM     Status:  MEDLINE    
PATIENTS, METHODS: As part of a prospective trial, 23 patients with cancers of the head and neck underwent [¹⁸F]fluorodeoxyglucose (FDG) PET before and during curative radiochemotherapy. Additionally, FMISO-PET studies 2 h and 4 h p.i. were done before treatment and after a mean dose of 11Gy, 23 Gy and 57 Gy during RCT. After coregistration, a dedicated software was used to define the gross tumour volume (GTV) by FDG PET for the primary tumour. This volume was overlaid to the FMISO images and hypoxia within the GTV was determined. The contrast between hypoxia determined by MISO2 and by MISO4 was investigated and analysed with the Wilcoxon-matched-pairs test.
RESULTS: Mean SUVmax in tumours of all examinations was 2.2 (stdev: 0.4, min: 1.3, max: 3.4) after 2 h and 2.4 (stdev: 0.7, min: 1.1, max: 4.4) after 4 h. In the neck musculature the mean SUVmax was 1.5 at both time points and the mean SUVmean decreased from 1.2 after 2 h to 1.1 after 4 h, respectively. These effects resulted in significantly rising contrast ratios from MISO2 to MISO4. The differently defined contrasts revealed significantly higher values for examinations 4 h p.i. (p < 0.002).
CONCLUSION: Data acquisition of [¹⁸F]FMISO should be done 4 h p.i. to gather the optimal contrast, preferably allowing further analysis, e. g. hypoxic sub volume definition for therapy planning.
N Abolmaali; R Haase; A Koch; D Zips; J Steinbach; M Baumann; J Kotzerke; K Zöphel
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-12-17
Journal Detail:
Title:  Nuklearmedizin. Nuclear medicine     Volume:  50     ISSN:  0029-5566     ISO Abbreviation:  Nuklearmedizin     Publication Date:  2011  
Date Detail:
Created Date:  2011-02-21     Completed Date:  2011-04-12     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  7609387     Medline TA:  Nuklearmedizin     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  22-7     Citation Subset:  IM    
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MeSH Terms
Carcinoma, Small Cell / radionuclide imaging*
Head and Neck Neoplasms / radionuclide imaging*
Image Enhancement / methods*
Middle Aged
Misonidazole / administration & dosage,  analogs & derivatives*,  diagnostic use
Positron-Emission Tomography / methods*
Radiopharmaceuticals / administration & dosage,  diagnostic use
Reproducibility of Results
Sensitivity and Specificity
Time Factors
Reg. No./Substance:
0/Radiopharmaceuticals; 13551-89-8/fluoromisonidazole; 8FE7LTN8XE/Misonidazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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