Document Detail

Two forkhead transcription factors regulate the division of cardiac progenitor cells by a Polo-dependent pathway.
MedLine Citation:
PMID:  22814603     Owner:  NLM     Status:  MEDLINE    
The development of a complex organ requires the specification of appropriate numbers of each of its constituent cell types, as well as their proper differentiation and correct positioning relative to each other. During Drosophila cardiogenesis, all three of these processes are controlled by jumeau (jumu) and Checkpoint suppressor homologue (CHES-1-like), two genes encoding forkhead transcription factors that we discovered utilizing an integrated genetic, genomic, and computational strategy for identifying genes expressed in the developing Drosophila heart. Both jumu and CHES-1-like are required during asymmetric cell division for the derivation of two distinct cardiac cell types from their mutual precursor and in symmetric cell divisions that produce yet a third type of heart cell. jumu and CHES-1-like control the division of cardiac progenitors by regulating the activity of Polo, a kinase involved in multiple steps of mitosis. This pathway demonstrates how transcription factors integrate diverse developmental processes during organogenesis.
Shaad M Ahmad; Terese R Tansey; Brian W Busser; Michael T Nolte; Neal Jeffries; Stephen S Gisselbrecht; Nasser M Rusan; Alan M Michelson
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Developmental cell     Volume:  23     ISSN:  1878-1551     ISO Abbreviation:  Dev. Cell     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-07-20     Completed Date:  2012-10-09     Revised Date:  2014-08-05    
Medline Journal Info:
Nlm Unique ID:  101120028     Medline TA:  Dev Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  97-111     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
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MeSH Terms
Cell Division / genetics*
Drosophila Proteins / genetics,  metabolism*,  physiology*
Drosophila melanogaster / embryology*,  genetics
Forkhead Transcription Factors / genetics,  metabolism*,  physiology
Gene Expression Regulation, Developmental / physiology
Heart / embryology*
Mitosis / genetics,  physiology
Protein-Serine-Threonine Kinases / genetics,  physiology*
Signal Transduction / physiology*
Stem Cells / cytology,  physiology
Transcription Factors / genetics,  metabolism*
Grant Support
Reg. No./Substance:
0/CHES-1-like protein, Drosophila; 0/Drosophila Proteins; 0/Forkhead Transcription Factors; 0/Transcription Factors; 0/jumu protein, Drosophila; EC 2.7.11.-/polo protein, Drosophila; EC Kinases

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