Document Detail

Two doses of pamidronate in infants with osteogenesis imperfecta.
MedLine Citation:
PMID:  18089634     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Current regimens of intravenous pamidronate for infants and children with osteogenesis imperfecta (OI) typically deliver 3-12 mg/kg/year of drug. We wished to ascertain the effect of pamidronate at 6 or 12 mg/kg/year on skeletal health in infants with OI. METHODS: We recruited 12 infants over a period of 4 years. Infants received either 6 or 12 mg/kg/year of pamidronate. Bone outcomes were assessed by skeletal surveys and DXA bone density measurements at baseline and at 12 months. RESULTS: Bone mass increased in both groups. Infants receiving 12 as opposed to 6 mg/kg/year pamidronate had increased spine bone density after adjusting for covariates at study entry (p = 0.04). Crush fractures improved or remained unchanged in all but one infant. Biochemical markers of bone turnover fell but remained within or above the normal range for age. Metaphyseal remodelling was not impaired. CONCLUSIONS: Pamidronate dose in infants may influence lumbar spine bone acquisition. Pamidronate improved vertebral size after prior crush fracturing and did not over-suppress bone turnover.
S Senthilnathan; E Walker; N J Bishop
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2007-12-18
Journal Detail:
Title:  Archives of disease in childhood     Volume:  93     ISSN:  1468-2044     ISO Abbreviation:  Arch. Dis. Child.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-04-22     Completed Date:  2008-05-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372434     Medline TA:  Arch Dis Child     Country:  England    
Other Details:
Languages:  eng     Pagination:  398-400     Citation Subset:  AIM; IM    
University of Sheffield, Western Bank, Sheffield S10 2TH, UK.
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MeSH Terms
Bone Density
Bone Density Conservation Agents / administration & dosage*
Bone Remodeling / drug effects
Child, Preschool
Diphosphonates / administration & dosage*
Drug Administration Schedule
Lumbar Vertebrae / chemistry
Osteogenesis Imperfecta / drug therapy*
Spine / chemistry
Treatment Outcome
Reg. No./Substance:
0/Bone Density Conservation Agents; 0/Diphosphonates; 40391-99-9/pamidronate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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