Document Detail

Two domains in vertebral development: antagonistic regulation by SHH and BMP4 proteins.
MedLine Citation:
PMID:  9636078     Owner:  NLM     Status:  MEDLINE    
It has previously been shown that the notochord grafted laterally to the neural tube enhances the differentiation of the vertebral cartilage at the expense of the derivatives of the dermomyotome. In contrast, the dorsomedial graft of a notochord inhibits cartilage differentiation of the dorsal part of the vertebra carrying the spinous process. Cartilage differentiation is preceded by the expression of transcription factors of the Pax family (Pax1/Pax9) in the ventrolateral domain and of the Msx family in the dorsal domain. The proliferation and differentiation of Msx-expressing cells in the dorsal precartilaginous domain of the vertebra are stimulated by BMP4, which acts upstream of Msx genes. It has previously been shown that the SHH protein arising from the notochord (and floor plate) is necessary for the survival and further development of Pax1/Pax9-expressing sclerotomal cells. We show here that SHH acts antagonistically to BMP4. SHH-producing cells grafted dorsally to the neural tube at E2 inhibit expression of Bmp4 and Msx genes and also inhibits the differentiation of the spinous process. We present a model that accounts for cartilage differentiation in the vertebra.
Y Watanabe; D Duprez; A H Monsoro-Burq; C Vincent; N M Le Douarin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  125     ISSN:  0950-1991     ISO Abbreviation:  Development     Publication Date:  1998 Jul 
Date Detail:
Created Date:  1998-08-27     Completed Date:  1998-08-27     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  2631-9     Citation Subset:  IM    
Institut d'Embryologie Cellulaire et Moléculaire du CNRS et Collège de France, 94736 Nogent-sur-Marne Cedex, France.
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MeSH Terms
Bone Morphogenetic Protein 4
Bone Morphogenetic Proteins / physiology*
Cartilage / growth & development*
Cell Differentiation / physiology*
Chick Embryo
DNA-Binding Proteins / genetics
Gene Expression Regulation, Developmental / genetics*
Hedgehog Proteins
In Situ Hybridization
Notochord / embryology
Paired Box Transcription Factors
Proteins / physiology*
RNA, Messenger / metabolism
Spine / embryology*
Tissue Transplantation
Transcription Factors / genetics,  physiology
Reg. No./Substance:
0/Bone Morphogenetic Protein 4; 0/Bone Morphogenetic Proteins; 0/DNA-Binding Proteins; 0/Hedgehog Proteins; 0/Paired Box Transcription Factors; 0/Proteins; 0/RNA, Messenger; 0/Trans-Activators; 0/Transcription Factors; 142661-96-9/PAX1 transcription factor

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