Document Detail

Two distinctive pathways for recruitment of naive and primed IgM+ B cells to the gut lamina propria.
MedLine Citation:
PMID:  15695334     Owner:  NLM     Status:  MEDLINE    
Intestinal IgA+ B cells are generated from IgM+ B cells by in situ class switching in two separate gut microenvironments: organized follicular structures and lamina propria (LP). However, the origin of IgM+ B cells in the gut LP is unknown. Transfer experiments to reconstitute IgM+ B cells and IgA plasma cells in LP of aly/aly mice, which are defective in all organized follicular structures because of an NF-kappaB-inducing kinase (NIK) mutation, revealed that naive B cells can directly migrate to the LP. This migration requires NIK-dependent activation of gut stromal cells. By contrast, the entry of gut-primed IgM+ B cells to the LP is independent of stromal cells with functional NIK. Our results indicate that naive B cells directly migrate to the LP by a distinct pathway from gut-primed B cells.
Keiichiro Suzuki; Bob Meek; Yasuko Doi; Tasuku Honjo; Sidonia Fagarasan
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Publication Detail:
Type:  Journal Article     Date:  2005-02-03
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  102     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-02-16     Completed Date:  2005-04-13     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2482-6     Citation Subset:  IM    
RIKEN Research Center for Allergy and Immunology, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
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MeSH Terms
B-Lymphocytes / immunology*,  physiology
Base Sequence
Bone Marrow Cells / immunology,  physiology
Cell Movement
DNA / genetics
Digestive System / cytology*,  immunology*
Immunoglobulin M / metabolism*
Mice, Inbred C57BL
Mice, Knockout
Mice, Mutant Strains
Mice, Transgenic
Peyer's Patches / cytology,  immunology
Reverse Transcriptase Polymerase Chain Reaction
Reg. No./Substance:
0/Immunoglobulin M; 9007-49-2/DNA

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