| Two distinctive pathways for recruitment of naive and primed IgM+ B cells to the gut lamina propria. | |
| | |
MedLine Citation:
|
PMID: 15695334 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Intestinal IgA+ B cells are generated from IgM+ B cells by in situ class switching in two separate gut microenvironments: organized follicular structures and lamina propria (LP). However, the origin of IgM+ B cells in the gut LP is unknown. Transfer experiments to reconstitute IgM+ B cells and IgA plasma cells in LP of aly/aly mice, which are defective in all organized follicular structures because of an NF-kappaB-inducing kinase (NIK) mutation, revealed that naive B cells can directly migrate to the LP. This migration requires NIK-dependent activation of gut stromal cells. By contrast, the entry of gut-primed IgM+ B cells to the LP is independent of stromal cells with functional NIK. Our results indicate that naive B cells directly migrate to the LP by a distinct pathway from gut-primed B cells. |
| | |
Authors:
|
Keiichiro Suzuki; Bob Meek; Yasuko Doi; Tasuku Honjo; Sidonia Fagarasan |
Related Documents
:
|
15983114 - Cell type-specific expression of beta-carotene 9',10'-monooxygenase in human tissues. 7288504 - Adenine, the precursor of nucleic acids in intestinal cells unable to synthesize purine... 1893944 - Expression of stress fibers in bullfrog mesothelial cells in response to tension. 9813394 - Lipopolysaccharide exhibits synergistic enhancement of butyrate-induced and retinoic ac... 21138904 - Ephrin a1 induces intercellular dissociation in ishikawa cells: possible implication of... 7841834 - Monocyte isolation by flow cytometer-monitored centrifugal elutriation: a preparative t... |
Publication Detail:
|
Type: Journal Article Date: 2005-02-03 |
Journal Detail:
|
Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 102 ISSN: 0027-8424 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 2005 Feb |
Date Detail:
|
Created Date: 2005-02-16 Completed Date: 2005-04-13 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: United States |
Other Details:
|
Languages: eng Pagination: 2482-6 Citation Subset: IM |
Affiliation:
|
RIKEN Research Center for Allergy and Immunology, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals B-Lymphocytes / immunology*, physiology Base Sequence Bone Marrow Cells / immunology, physiology Cell Movement DNA / genetics Digestive System / cytology*, immunology* Immunoglobulin M / metabolism* Mice Mice, Inbred C57BL Mice, Knockout Mice, Mutant Strains Mice, Transgenic Peyer's Patches / cytology, immunology Reverse Transcriptase Polymerase Chain Reaction |
| Chemical | |
Reg. No./Substance:
|
0/Immunoglobulin M; 9007-49-2/DNA |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Proteolysis of SNARE proteins alters facilitation and depression in a specific way.
Next Document: Disturbed Ca2+ signaling and apoptosis of medium spiny neurons in Huntington's disease.