Document Detail

Two distinct ubiquitin immunoreactive senile plaques in Alzheimer's disease: relationship with the intellectual status in 29 cases.
MedLine Citation:
PMID:  8396836     Owner:  NLM     Status:  MEDLINE    
The aim of this study was the analysis of the development of neurofibrillary tangles (NFT) and senile plaques (SP) during aging and senile dementia of the Alzheimer type. The lesions stained by ubiquitin, tau and beta A4 antibodies were studied in Brodmann's area 22 (superior temporal gyrus) in 29 cases. Samples were from a group of women over 75 years of age, psychometrically assessed and either normal or affected by Alzheimer's disease at various degrees of severity. NFT were less numerous when revealed by ubiquitin than by tau antibodies, suggesting that ubiquitin immunoreactivity appeared later in the course of the disease. Ubiquitin immunoreactive (IR) SP were made of clusters of IR neurites usually organized around a central amyloid core. Two types of ubiquitin-IR SP were designated. "Globular neurite SP" contained weakly immunostained globular neurites. They were densest in the least affected cases. However, they were not seen in every normal or lightly affected case, and were always present in the most affected ones. The density of these globular neurite SP was not significantly correlated with the severity of dementia, nor with the density of the lesions stained by tau antibodies (neuritic component of SP, NFT and neuropil threads) or by beta A4 antibodies (diffuse or dense deposits). The "curly neurite" type of SP contained curly neurites strongly immunostained by ubiquitin antibodies. They exhibited the highest density in the most affected cases, where they were always present. They were lacking in the least affected cases. They were always found together with the globular neurite SP.(ABSTRACT TRUNCATED AT 250 WORDS)
Y He; P Delaère; C Duyckaerts; M Wasowicz; F Piette; J J Hauw
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta neuropathologica     Volume:  86     ISSN:  0001-6322     ISO Abbreviation:  Acta Neuropathol.     Publication Date:  1993  
Date Detail:
Created Date:  1993-10-08     Completed Date:  1993-10-08     Revised Date:  2007-11-09    
Medline Journal Info:
Nlm Unique ID:  0412041     Medline TA:  Acta Neuropathol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  109-16     Citation Subset:  IM    
Laboratoire de Neuropathologie R. Escourolle, INSERM U360, Hôpital de la Salpêtrière, Paris, France.
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MeSH Terms
Aged, 80 and over
Alzheimer Disease / immunology,  pathology*,  psychology
Amyloid beta-Protein / immunology
Intelligence Tests*
Neurites / ultrastructure
Neurofibrillary Tangles / pathology
Prospective Studies
Ubiquitins / immunology,  metabolism*
tau Proteins / immunology
Reg. No./Substance:
0/Amyloid beta-Protein; 0/Ubiquitins; 0/tau Proteins

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