| Two distinct types of speckled lentiginous nevi characterized by macular versus papular speckles. | |
| | |
MedLine Citation:
|
PMID: 16319475 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Speckled lentiginous nevus (SLN; synonym: nevus spilus) is a darkly spotted light-brown macule that mostly occurs as an isolated lesion of rather limited dimensions but sometimes may involve large areas of the body. So far, this skin disorder has been considered to represent one clinical entity. OBJECTIVE: Because SLN is occasionally associated with complex birth defects such as phacomatosis pigmentovascularis, phacomatosis pigmentokeratotica, or SLN syndrome, we tested our idea that two different types of SLN may exist, each one associated with a particular syndrome. METHODS: A review of case reports on SLN published during the years 1970-2004 was performed. RESULTS: This evaluation of cases provided evidence that two different types of SLN exist, in the form of macular versus papular SLN, each one being related to a specific syndrome. Macular SLN is characterized by a tannish-brown background with darker flat speckles. The distribution of speckles is rather even and resembles a polka-dot pattern. Histopathologically, this type of SLN is characterized by what has been called a 'jentigo' pattern in the darker speckles and by some nests of melanocytes at the dermoepidermal junction at the tips of the papillae, whereas the background pigmentation shows the microscopical features of a lentigo. Papular SLN is characterized by a light-brown macule superimposed by multiple melanocytic nevi in the form of papules or nodules that show a more uneven distribution reminiscent of a star map. Small dark macules may likewise be present. Histopathologically, the papular component consists of dermal or compound melanocytic nevi. A separation of the two types of SLN is important because our analysis showed that macular SLN is a hallmark of a particular type of phacomatosis pigmentovascularis, whereas papular SLN is typically present in phacomatosis pigmentokeratotica as well as in SLN syndrome. CONCLUSIONS: Macular SLN and papular SLN appear to be two distinct cutaneous entities. This dichotomy may turn out to be important when such nevi will be analyzed at the molecular level. |
| | |
Authors:
|
Helena Vidaurri-de la Cruz; Rudolf Happle |
Related Documents
:
|
2604805 - Gerstmann tetrad in leopard syndrome. 7004385 - The role of the term schizophrenia in the decline of diagnoses of multiple personality. 11482345 - Typical ocular findings in a patient with multiple endocrine neoplasia type 2b syndrome. 923405 - Multiple mucosal neuroma (mmn) or multiple endocrine neoplasia (men) type 3 syndrome. o... 16397715 - Ocular findings in malaysian children with down syndrome. 19950745 - Acute respiratory distress syndrome: rapid and significant response to volume-controlle... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
|
Title: Dermatology (Basel, Switzerland) Volume: 212 ISSN: 1018-8665 ISO Abbreviation: Dermatology (Basel) Publication Date: 2006 |
Date Detail:
|
Created Date: 2005-12-01 Completed Date: 2006-01-09 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9203244 Medline TA: Dermatology Country: Switzerland |
Other Details:
|
Languages: eng Pagination: 53-8 Citation Subset: IM |
Copyright Information:
|
Copyright (c) 2006 S. Karger AG, Basel. |
Affiliation:
|
Department of Dermatology, Philipp University of Marburg, Marburg, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Humans Nevus, Pigmented / classification, pathology* Skin / pathology Skin Neoplasms / classification, pathology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Ultrasound mapping of lymph node and subcutaneous metastases in patients with cutaneous melanoma: re...
Next Document: Terbinafine-induced subacute cutaneous lupus erythematosus.