Document Detail


Two distinct syndromes of lymphoma-associated AL amyloidosis: a case series and review of the literature.
MedLine Citation:
PMID:  20872959     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Light chain (AL) amyloidosis has a rare association with non-Hodgkin lymphoma (NHL). Both peritumoral and systemic AL amyloidosis have been reported, but a detailed description of these syndromes is lacking. We describe 10 patients with lymphoma associated AL amyloidosis. NHL patients with peritumoral amyloidosis had low or undetectable levels of monoclonal (M) protein, mostly single organ involvement(lung or soft tissue), and underlying extranodal marginal zone lymphoma, mucosa associated lymphoid tissue subtype. NHL patients with systemic amyloidosis had high levels of M-protein, multiorgan involvement with frequent cardiac involvement, and predominantly underlying lymphoplasmacytic lymphoma. Systemic amyloidosis was associated with inferior outcomes
Authors:
David Telio; Denis Bailey; Christine Chen; Michael Crump; Donna Reece; Vishal Kukreti
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Publication Detail:
Type:  Comparative Study; Letter; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  American journal of hematology     Volume:  85     ISSN:  1096-8652     ISO Abbreviation:  Am. J. Hematol.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-27     Completed Date:  2010-10-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7610369     Medline TA:  Am J Hematol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  805-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Amyloidosis / etiology*,  metabolism,  pathology
Antibodies, Monoclonal / administration & dosage
Antineoplastic Agents, Alkylating / administration & dosage
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Female
Humans
Immunoglobulin G / analysis
Immunoglobulin Light Chains / analysis*
Immunoglobulin M / analysis*
Lymphoma, B-Cell / complications*,  drug therapy,  metabolism,  pathology
Male
Middle Aged
Organ Specificity
Paraneoplastic Syndromes / etiology*,  metabolism,  pathology
Prognosis
Retrospective Studies
Treatment Outcome
Grant Support
ID/Acronym/Agency:
DK34854/DK/NIDDK NIH HHS; DK43495/DK/NIDDK NIH HHS; HL077765/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Antineoplastic Agents, Alkylating; 0/Immunoglobulin G; 0/Immunoglobulin Light Chains; 0/Immunoglobulin M; 0/rituximab

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