| Two distinct syndromes of lymphoma-associated AL amyloidosis: a case series and review of the literature. | |
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MedLine Citation:
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PMID: 20872959 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Light chain (AL) amyloidosis has a rare association with non-Hodgkin lymphoma (NHL). Both peritumoral and systemic AL amyloidosis have been reported, but a detailed description of these syndromes is lacking. We describe 10 patients with lymphoma associated AL amyloidosis. NHL patients with peritumoral amyloidosis had low or undetectable levels of monoclonal (M) protein, mostly single organ involvement(lung or soft tissue), and underlying extranodal marginal zone lymphoma, mucosa associated lymphoid tissue subtype. NHL patients with systemic amyloidosis had high levels of M-protein, multiorgan involvement with frequent cardiac involvement, and predominantly underlying lymphoplasmacytic lymphoma. Systemic amyloidosis was associated with inferior outcomes |
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Authors:
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David Telio; Denis Bailey; Christine Chen; Michael Crump; Donna Reece; Vishal Kukreti |
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Publication Detail:
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Type: Comparative Study; Letter; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: American journal of hematology Volume: 85 ISSN: 1096-8652 ISO Abbreviation: Am. J. Hematol. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-27 Completed Date: 2010-10-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7610369 Medline TA: Am J Hematol Country: United States |
Other Details:
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Languages: eng Pagination: 805-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Amyloidosis / etiology*, metabolism, pathology Antibodies, Monoclonal / administration & dosage Antineoplastic Agents, Alkylating / administration & dosage Antineoplastic Combined Chemotherapy Protocols / therapeutic use Female Humans Immunoglobulin G / analysis Immunoglobulin Light Chains / analysis* Immunoglobulin M / analysis* Lymphoma, B-Cell / complications*, drug therapy, metabolism, pathology Male Middle Aged Organ Specificity Paraneoplastic Syndromes / etiology*, metabolism, pathology Prognosis Retrospective Studies Treatment Outcome |
| Grant Support | |
ID/Acronym/Agency:
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DK34854/DK/NIDDK NIH HHS; DK43495/DK/NIDDK NIH HHS; HL077765/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/Antineoplastic Agents, Alkylating; 0/Immunoglobulin G; 0/Immunoglobulin Light Chains; 0/Immunoglobulin M; 0/rituximab |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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