Document Detail


Two distinct mechanisms for long-range patterning by Decapentaplegic in the Drosophila wing.
MedLine Citation:
PMID:  8632795     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Secreted signalling molecules provide cells with positional information that organizes long-range pattern during the development of multicellular animals. Evidence is presented that localized expression of Decapentaplegic instructs cells about their position along the anterior-posterior axis of the Drosophila wing in two distinct ways. One mechanism is based on the local concentration of the secreted protein; the other is based on the ability of the cells to retain an instruction received at an earlier time when their progenitors were in close proximity to the signal. Both mechanisms are involved in axis formation.
Authors:
T Lecuit; W J Brook; M Ng; M Calleja; H Sun; S M Cohen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nature     Volume:  381     ISSN:  0028-0836     ISO Abbreviation:  Nature     Publication Date:  1996 May 
Date Detail:
Created Date:  1996-07-03     Completed Date:  1996-07-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0410462     Medline TA:  Nature     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  387-93     Citation Subset:  IM    
Affiliation:
European Molecular Biology Laboratory, Heidelberg, Germany.
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MeSH Terms
Descriptor/Qualifier:
Animals
Clone Cells
DNA-Binding Proteins / genetics
Drosophila / embryology,  genetics
Drosophila Proteins*
Embryo, Nonmammalian / cytology*,  physiology
Embryonic Induction* / genetics,  physiology
Gene Expression Regulation, Developmental
Homeodomain Proteins*
Insect Hormones / genetics,  physiology*
Morphogenesis / genetics,  physiology
Nerve Tissue Proteins / genetics
Signal Transduction*
T-Box Domain Proteins*
Transcription Factors / genetics
Wing / embryology
Chemical
Reg. No./Substance:
0/DNA-Binding Proteins; 0/Drosophila Proteins; 0/Homeodomain Proteins; 0/Insect Hormones; 0/Nerve Tissue Proteins; 0/T-Box Domain Proteins; 0/Transcription Factors; 0/dpp protein, Drosophila; 0/sal protein, Drosophila; 146635-31-6/bifid protein, Drosophila
Comments/Corrections
Comment In:
Nature. 1996 May 30;381(6581):367-8   [PMID:  8632790 ]
Erratum In:
Nature 1996 Jul 4;382(6586):93

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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