Document Detail

Two distinct human POM121 genes: requirement for the formation of nuclear pore complexes.
MedLine Citation:
PMID:  17900573     Owner:  NLM     Status:  MEDLINE    
Pom121 is one of the integral membrane components of the nuclear pore complex (NPC) in vertebrate cells. Unlike rodent cells carrying a single POM121 gene, human cells possess multiple POM121 gene loci on chromosome 7q11.23, as a consequence of complex segmental-duplications in this region during human evolution. In HeLa cells, two "full-length" Pom121 are transcribed and translated by two distinct genetic loci. RNAi experiments showed that efficient depletion of both Pom121 proteins significantly reduces assembled NPCs on nuclear envelope. Pom121-depletion also induced clustering of NPCs, indicating its role on maintenance of NPC structure/organization.
Tomoko Funakoshi; Kazuhiro Maeshima; Kazuhide Yahata; Sumio Sugano; Fumio Imamoto; Naoko Imamoto
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-09-21
Journal Detail:
Title:  FEBS letters     Volume:  581     ISSN:  0014-5793     ISO Abbreviation:  FEBS Lett.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-10-12     Completed Date:  2008-01-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  4910-6     Citation Subset:  IM    
Cellular Dynamics Laboratory, Discovery Research Institute, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
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MeSH Terms
5' Flanking Region
Base Sequence
Cell Nucleus / ultrastructure
Chromosome Mapping
Cloning, Molecular
Gene Duplication*
Hela Cells
Membrane Glycoproteins / chemistry,  genetics*,  metabolism
Molecular Sequence Data
Nuclear Pore / ultrastructure*
Protein Structure, Tertiary
RNA Interference
Reg. No./Substance:
0/Membrane Glycoproteins; 0/POM121 protein, human

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