Document Detail

Two distinct channels of olfactory bulb output.
MedLine Citation:
PMID:  22841316     Owner:  NLM     Status:  In-Data-Review    
Rhythmic neural activity is a hallmark of brain function, used ubiquitously to structure neural information. In mammalian olfaction, repetitive sniffing sets the principal rhythm but little is known about its role in sensory coding. Here, we show that mitral and tufted cells, the two main classes of olfactory bulb projection neurons, tightly lock to this rhythm, but to opposing phases of the sniff cycle. This phase shift is established by local inhibition that selectively delays mitral cell activity. Furthermore, while tufted cell phase is unperturbed in response to purely excitatory odorants, mitral cell phase is advanced in a graded, stimulus-dependent manner. Thus, phase separation by inhibition forms the basis for two distinct channels of olfactory processing.
Izumi Fukunaga; Manuel Berning; Mihaly Kollo; Anja Schmaltz; Andreas T Schaefer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neuron     Volume:  75     ISSN:  1097-4199     ISO Abbreviation:  Neuron     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-07-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8809320     Medline TA:  Neuron     Country:  United States    
Other Details:
Languages:  eng     Pagination:  320-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Behavioural Neurophysiology, Max-Planck-Institute for Medical Research, Jahnstr. 29, 69120 Heidelberg, Germany.
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