Document Detail

Two-dimensional and three-dimensional oxygen mapping by 3He-MRI validation in a lung phantom.
MedLine Citation:
PMID:  15856240     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to validate oxygen-sensitive 3He-MRI in noninvasive determination of the regional, two- and three-dimensional distribution of oxygen partial pressure. In a gas-filled elastic silicon ventilation bag used as a lung phantom, oxygen sensitive two- and three-dimensional 3He-MRI measurements were performed at different oxygen concentrations which had been equilibrated in a range of normal and pathologic values. The oxygen partial pressure distribution was determined from 3He-MRI using newly developed software allowing for mapping of oxygen partial pressure. The reference bulk oxygen partial pressure inside the phantom was measured by conventional respiratory gas analysis. In two-dimensional measurements, image-based and gas-analysis results correlated with r=0.98; in three-dimensional measurements the between-methods correlation coefficient was r=0.89. The signal-to-noise ratio of three-dimensional measurements was about half of that of two-dimensional measurements and became critical (below 3) in some data sets. Oxygen-sensitive 3He-MRI allows for noninvasive determination of the two- and three-dimensional distribution of oxygen partial pressure in gas-filled airspaces.
Klaus Kurt Gast; Wolfgang G Schreiber; Annette Herweling; Frank Lehmann; Gabor Erdös; Joerg Schmiedeskamp; Hans-Ulrich Kauczor; Balthasar Eberle
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Validation Studies     Date:  2005-04-23
Journal Detail:
Title:  European radiology     Volume:  15     ISSN:  0938-7994     ISO Abbreviation:  Eur Radiol     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-08-10     Completed Date:  2005-12-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9114774     Medline TA:  Eur Radiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1915-22     Citation Subset:  IM    
Department of Radiology, Johannes Gutenberg University Hospital, Langenbeckstrasse 1, 55131, Mainz, Germany.
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MeSH Terms
Helium / diagnostic use*
Image Processing, Computer-Assisted / methods*
Imaging, Three-Dimensional / methods*
Inhalation / physiology
Isotopes / diagnostic use
Lung / metabolism*
Magnetic Resonance Imaging / methods*
Oxygen / administration & dosage
Oxygen Consumption / physiology*
Partial Pressure
Phantoms, Imaging*
Reg. No./Substance:
0/Isotopes; 7440-59-7/Helium; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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