| Two different sides of 'chemobrain': determinants and nondeterminants of self-perceived cognitive dysfunction in a prospective, randomized, multicenter study. | |
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MedLine Citation:
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PMID: 20127909 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Complaints of cognitive dysfunction are frequent among cancer patients. Many studies have identified neuropsychological compromise associated with cancer and cancer therapy; however, the neuropsychological compromise was not related to self-reported cognitive dysfunction. In this prospective study, the authors examined if confounding factors masked an underlying association of self-perceived cognitive function with actual cognitive performance. Determinants of self-perceived cognitive dysfunction were investigated. METHODS: Self-perceived cognitive function and cognitive performance were assessed before treatment, at the end of treatment, and 1 year after baseline in 101 breast cancer patients randomized to standard versus intensified chemotherapy. Linear mixed-effects models were applied to test the relationships of performance on neuropsychological tests, patient characteristics, and treatment variables to self-reported cognitive function. Change of cognitive performance was tested as a predictor of change in self-reports. RESULTS: Self-perceived cognitive function deteriorated during chemotherapy and had partially recovered 1 year after diagnosis. The personality trait negative affectivity, current depression, and chemotherapy regimen were consistently related to cognitive self-reports. No significant associations with performance in any of the 12 cognitive tests emerged. Change of cognitive performance was not reflected in self-reports of cognitive function. CONCLUSIONS: Neuropsychological compromise and self-perceived cognitive dysfunction are independent phenomena in cancer patients. Generally, cancer-associated neuropsychological compromise is not noticed by affected patients, but negative affectivity and treatment burden induce pessimistic self-appraisals of cognitive functioning regardless of the presence of neuropsychological compromise. Clinicians should consider this when determining adequate therapy for patients who complain of 'chemobrain'. |
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Authors:
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Kerstin Hermelink; Helmut Küchenhoff; Michael Untch; Ingo Bauerfeind; Michael Patrick Lux; Markus Bühner; Juliane Manitz; Veronika Fensterer; Karin Münzel |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Randomized Controlled Trial |
Journal Detail:
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Title: Psycho-oncology Volume: 19 ISSN: 1099-1611 ISO Abbreviation: Psychooncology Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-26 Completed Date: 2011-01-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9214524 Medline TA: Psychooncology Country: England |
Other Details:
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Languages: eng Pagination: 1321-8 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 John Wiley & Sons, Ltd. |
Affiliation:
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Department of Gynecology and Obstetrics, Ludwig Maximilian University, Munich, Germany. kerstin.hermelink@med.uni-muenchen.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Affect* Aged Antineoplastic Combined Chemotherapy Protocols / adverse effects* Breast Neoplasms / drug therapy*, psychology Cognition / drug effects* Cognition Disorders / chemically induced*, diagnosis, psychology Female Follow-Up Studies Humans Middle Aged Neuropsychological Tests Perception Prospective Studies Quality of Life Self Report |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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