Document Detail


Two different sides of 'chemobrain': determinants and nondeterminants of self-perceived cognitive dysfunction in a prospective, randomized, multicenter study.
MedLine Citation:
PMID:  20127909     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Complaints of cognitive dysfunction are frequent among cancer patients. Many studies have identified neuropsychological compromise associated with cancer and cancer therapy; however, the neuropsychological compromise was not related to self-reported cognitive dysfunction. In this prospective study, the authors examined if confounding factors masked an underlying association of self-perceived cognitive function with actual cognitive performance. Determinants of self-perceived cognitive dysfunction were investigated.
METHODS: Self-perceived cognitive function and cognitive performance were assessed before treatment, at the end of treatment, and 1 year after baseline in 101 breast cancer patients randomized to standard versus intensified chemotherapy. Linear mixed-effects models were applied to test the relationships of performance on neuropsychological tests, patient characteristics, and treatment variables to self-reported cognitive function. Change of cognitive performance was tested as a predictor of change in self-reports.
RESULTS: Self-perceived cognitive function deteriorated during chemotherapy and had partially recovered 1 year after diagnosis. The personality trait negative affectivity, current depression, and chemotherapy regimen were consistently related to cognitive self-reports. No significant associations with performance in any of the 12 cognitive tests emerged. Change of cognitive performance was not reflected in self-reports of cognitive function.
CONCLUSIONS: Neuropsychological compromise and self-perceived cognitive dysfunction are independent phenomena in cancer patients. Generally, cancer-associated neuropsychological compromise is not noticed by affected patients, but negative affectivity and treatment burden induce pessimistic self-appraisals of cognitive functioning regardless of the presence of neuropsychological compromise. Clinicians should consider this when determining adequate therapy for patients who complain of 'chemobrain'.
Authors:
Kerstin Hermelink; Helmut Küchenhoff; Michael Untch; Ingo Bauerfeind; Michael Patrick Lux; Markus Bühner; Juliane Manitz; Veronika Fensterer; Karin Münzel
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Publication Detail:
Type:  Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  Psycho-oncology     Volume:  19     ISSN:  1099-1611     ISO Abbreviation:  Psychooncology     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-26     Completed Date:  2011-01-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9214524     Medline TA:  Psychooncology     Country:  England    
Other Details:
Languages:  eng     Pagination:  1321-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 John Wiley & Sons, Ltd.
Affiliation:
Department of Gynecology and Obstetrics, Ludwig Maximilian University, Munich, Germany. kerstin.hermelink@med.uni-muenchen.de
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MeSH Terms
Descriptor/Qualifier:
Adult
Affect*
Aged
Antineoplastic Combined Chemotherapy Protocols / adverse effects*
Breast Neoplasms / drug therapy*,  psychology
Cognition / drug effects*
Cognition Disorders / chemically induced*,  diagnosis,  psychology
Female
Follow-Up Studies
Humans
Middle Aged
Neuropsychological Tests
Perception
Prospective Studies
Quality of Life
Self Report

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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