Document Detail

Two consecutive high-fat meals affect endothelial-dependent vasodilation, oxidative stress and cellular microparticles in healthy men.
MedLine Citation:
PMID:  16689751     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: A large body of evidence has accumulated indicating a relation between postprandial hyperglycemia and hypertriglyceridemia, and the risk of cardiovascular disease. OBJECTIVE: We studied possible mechanisms underlying the postprandial proatherogenic state by exposing healthy males to two consecutive high-fat mixed meals. PATIENTS/METHODS: Seventeen healthy males [age 25.4 +/- 3 years, body mass index 23.6 +/- 2 kg m(-2)] were studied during two randomized visits. During the meal visit, subjects consumed standardized meals (50 g of fat, 55 g of carbohydrates and 30 g of proteins) as breakfast and 4 h later as lunch. During the control visit, subjects remained fasted. Prior to each blood collection (before and every 2 h after the first meal), flow-mediated dilation (FMD) of the brachial artery was measured. RESULTS: Although within the normal range, postprandial plasma glucose and triacylglycerol concentrations increased significantly, especially after the second meal, as compared with baseline (4.8 +/- 0.3 to 5.4 +/- 0.4, 0.8 +/- 0.2 to 1.7 +/- 0.7 mmol L(-1), respectively; both P < 0.05) and the fasting visit. After the second meal, FMD was significantly impaired (6.9% vs. 3.7%, P < 0.05) whereas oxidized low-density lipoprotein (oxLDL)/LDL cholesterol ratio and malondialdehyde concentrations were markedly elevated (both P < 0.01). Finally, an increase in total microparticle (MP) numbers was observed during the meal visit (P < 0.05). CONCLUSIONS: In healthy males, after two consecutive fat-rich meals, mild elevations in plasma glucose and triacylglycerol were paralleled by impaired FMD, increased markers of oxidative stress and circulating MPs, in particular, after the second meal. These findings may have consequences for subjects with postprandial dysmetabolism, including those with Type 2 diabetes.
M E Tushuizen; R Nieuwland; P G Scheffer; A Sturk; R J Heine; M Diamant
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of thrombosis and haemostasis : JTH     Volume:  4     ISSN:  1538-7933     ISO Abbreviation:  J. Thromb. Haemost.     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-05-12     Completed Date:  2006-07-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101170508     Medline TA:  J Thromb Haemost     Country:  England    
Other Details:
Languages:  eng     Pagination:  1003-10     Citation Subset:  IM    
Department of Endocrinology/Diabetes Center, VU University Medical Center, 1007 MB Amsterdam, The Netherlands.
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MeSH Terms
Blood Glucose / analysis
Cholesterol, HDL / blood
Dietary Fats / administration & dosage*,  pharmacology
Endothelium, Vascular / physiology*
Fatty Acids, Nonesterified / blood
Flow Cytometry
Insulin / blood
Lipoproteins, LDL
Oxidative Stress*
Postprandial Period
Reference Values
Vasodilation / drug effects*
Reg. No./Substance:
0/Blood Glucose; 0/Cholesterol, HDL; 0/Dietary Fats; 0/Fatty Acids, Nonesterified; 0/Lipoproteins, LDL; 0/oxidized low density lipoprotein; 11061-68-0/Insulin

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