| Two clusters of serum midkine levels in drug-naive patients with schizophrenia. | |
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MedLine Citation:
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PMID: 12782336 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Midkine (MK) is a heparin-binding growth factor implicated in various biological phenomena such as development of the hippocampus and anxiety. We evaluated serum MK levels of drug-naive (n=15) and medicated (n=25) patients with schizophrenia, and age- and sex-matched normal controls (n=38). The patients showed two clusters in the levels. Four drug-naive patients (26.7%) and two medicated patients (8.0%) had abnormally high values, but no controls did, there being a significant difference in the numbers (P=0.003, Fisher's exact test). Furthermore, in other patients, the mean MK levels in drug-naive schizophrenia (0.30+/-0.10 ng/ml) were significantly (P=0.018, Fisher's protected least significant difference test) decreased than those in the controls (0.40+/-0.12 ng/ml). These suggest that there are two clusters of serum MK abnormalities in drug-naive patients with schizophrenia. |
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Authors:
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Eiji Shimizu; Kenji Hashimoto; Ragaa H M Salama; Hiroyuki Watanabe; Naoya Komatsu; Naoe Okamura; Kaori Koike; Naoyuki Shinoda; Michiko Nakazato; Chikara Kumakiri; Sin-ichi Okada; Hisako Muramatsu; Takashi Muramatsu; Masaomi Iyo |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Neuroscience letters Volume: 344 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 2003 Jun |
Date Detail:
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Created Date: 2003-06-03 Completed Date: 2003-07-14 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 95-8 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuou-ku, Chiba 260-8670, Japan. eiji@faculty.chiba-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Biological Markers / blood Carrier Proteins / blood* Cytokines / blood* Enzyme-Linked Immunosorbent Assay Female Humans Male Middle Aged Schizophrenia / blood*, drug therapy |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Carrier Proteins; 0/Cytokines; 137497-38-2/midkine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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