Document Detail

Two clusters of serum midkine levels in drug-naive patients with schizophrenia.
MedLine Citation:
PMID:  12782336     Owner:  NLM     Status:  MEDLINE    
Midkine (MK) is a heparin-binding growth factor implicated in various biological phenomena such as development of the hippocampus and anxiety. We evaluated serum MK levels of drug-naive (n=15) and medicated (n=25) patients with schizophrenia, and age- and sex-matched normal controls (n=38). The patients showed two clusters in the levels. Four drug-naive patients (26.7%) and two medicated patients (8.0%) had abnormally high values, but no controls did, there being a significant difference in the numbers (P=0.003, Fisher's exact test). Furthermore, in other patients, the mean MK levels in drug-naive schizophrenia (0.30+/-0.10 ng/ml) were significantly (P=0.018, Fisher's protected least significant difference test) decreased than those in the controls (0.40+/-0.12 ng/ml). These suggest that there are two clusters of serum MK abnormalities in drug-naive patients with schizophrenia.
Eiji Shimizu; Kenji Hashimoto; Ragaa H M Salama; Hiroyuki Watanabe; Naoya Komatsu; Naoe Okamura; Kaori Koike; Naoyuki Shinoda; Michiko Nakazato; Chikara Kumakiri; Sin-ichi Okada; Hisako Muramatsu; Takashi Muramatsu; Masaomi Iyo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neuroscience letters     Volume:  344     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-06-03     Completed Date:  2003-07-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  95-8     Citation Subset:  IM    
Department of Psychiatry, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuou-ku, Chiba 260-8670, Japan.
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MeSH Terms
Biological Markers / blood
Carrier Proteins / blood*
Cytokines / blood*
Enzyme-Linked Immunosorbent Assay
Middle Aged
Schizophrenia / blood*,  drug therapy
Reg. No./Substance:
0/Biological Markers; 0/Carrier Proteins; 0/Cytokines; 137497-38-2/midkine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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