Document Detail


Two cleavage products of the Drosophila accessory gland protein ovulin can independently induce ovulation.
MedLine Citation:
PMID:  15640356     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Proteins and peptides in Drosophila melanogaster seminal fluid induce mated females to increase their rates of egg deposition. One seminal-fluid protein, ovulin (Acp26Aa), stimulates an early step in the egg-laying process, the release of oocytes by the ovary. Ovulin, upon transfer to females, is cleaved sequentially within the mated female's reproductive tract. Here, we show that systemic ectopic expression of ovulin is sufficient to stimulate ovulation in unmated females. By using this assay to assess the functionality of ovulin's cleavage products, we find that two of the four cleavage products of ovulin can stimulate ovulation independently. Thus, ovulin's cleavage in mated females is not destructive and instead may liberate additional functional products with potential to modulate ovulation independently.
Authors:
Yael Heifetz; Laura N Vandenberg; Heather I Cohn; Mariana F Wolfner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.     Date:  2005-01-07
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  102     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2005-01-19     Completed Date:  2005-03-15     Revised Date:  2014-01-08    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  743-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Drosophila Proteins / metabolism*,  physiology*
Female
Male
Mutagenesis, Site-Directed
Ovulation*
Peptide Fragments / pharmacology,  physiology*
Peptides / metabolism,  physiology*
Seminal Plasma Proteins / metabolism*,  physiology
Sequence Deletion
Grant Support
ID/Acronym/Agency:
HD38921/HD/NICHD NIH HHS; R01 HD038921/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Acp26Aa protein, Drosophila; 0/Drosophila Proteins; 0/Peptide Fragments; 0/Peptides; 0/Seminal Plasma Proteins
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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