Document Detail

Two cases of synovitis, acne, pustulosis, osteitis--SAPHO syndrome.
MedLine Citation:
PMID:  17684587     Owner:  NLM     Status:  MEDLINE    
Synovitis, acne, pustulosis, osteitis (SAPHO) syndrome is rare with yet unknown prevalence. The difficulty in recognizing the syndrome is due to the very wide diversity of its signs and symptoms, the lack of skin manifestations in many cases and to confusion in medical terminology in describing this syndrome. In this paper, we present two cases with characteristic bone lesions in bone scan and in radiology images that are considered to be SAPHO syndrome. In the first case the characteristic bone single photon emission tomography scan findings in a patient with spine involvement supposed by bone biopsy but were not followed by characteristic skin manifestations. The point of interest of this case lies on the significant improvement of both symptoms and scintigraphic findings after treatment with biphosphonates. In the second case the diagnosis was also based on the characteristic bone scan findings, although the patient referred to us for staging of prostate cancer. Detailed history and clinical examination revealed skin manifestations of the syndrome.
Trifon Spyridonidis; Costas Giannakenas; Nikos Papandrianos; Panagiota Barla; Dimitris J Apostolopoulos
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Hellenic journal of nuclear medicine     Volume:  10     ISSN:  1790-5427     ISO Abbreviation:  Hell J Nucl Med     Publication Date:    2007 May-Aug
Date Detail:
Created Date:  2007-08-08     Completed Date:  2007-11-07     Revised Date:  2010-08-23    
Medline Journal Info:
Nlm Unique ID:  101257471     Medline TA:  Hell J Nucl Med     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  109-12     Citation Subset:  IM    
University of Patras, Medical School, Department of Nuclear Medicine, Regional University Hospital of Patras, Rion, Patras 26500, Greece.
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MeSH Terms
Acne Vulgaris / complications,  diagnosis*
Acquired Hyperostosis Syndrome / diagnosis*
Aged, 80 and over
Bone Diseases / pathology
Bone and Bones / pathology
Osteitis / complications,  diagnosis*
Prostatic Neoplasms / complications
Radionuclide Imaging / methods
Synovitis / complications,  diagnosis*
Tomography, X-Ray Computed / methods
Whole Body Imaging
Comment In:
Hell J Nucl Med. 2010 Jan-Apr;13(1):73-5   [PMID:  20411180 ]

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