Document Detail

Two cases of Sjögren's syndrome with multiple bullae.
MedLine Citation:
PMID:  11868599     Owner:  NLM     Status:  MEDLINE    
Here, we report two rare female cases of Sjögren's syndrome with multiple bullae, involving a 66- and a 51-year-old. Neither had any obvious pulmonary complaint. Chest radiographs and high-resolution CT (HRCT) scans showed interstitial linear and nodular opacities and multiple bullae. In the first case spirometry indicated an obstructive change judged by FEV1.0 and V50/V25. In both cases, histologic examination of the lung revealed thickening of alveolar septa and interstitial mononuclear cell infiltration. In the first case the bullae decreased in size with corticosteroid treatment. Airway narrowing due to peribronchiolar mononuclear cell infiltration causes a check-valve mechanism, which may lead to bullae formation. Although a rare occurrence, it is important to recognize that cystic or bullous lung disease can accompany Sjögren's syndrome.
Osamu Sakamoto; Naoki Saita; Makoto Ando; Hirotsugu Kohrogi; Moritaka Suga; Masayuki Ando
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Internal medicine (Tokyo, Japan)     Volume:  41     ISSN:  0918-2918     ISO Abbreviation:  Intern. Med.     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-02-28     Completed Date:  2002-10-30     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9204241     Medline TA:  Intern Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  124-8     Citation Subset:  IM    
First Department of Internal Medicine, Kumamoto University School of Medicine.
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MeSH Terms
Airway Obstruction / etiology,  pathology,  radiography
Autoimmune Diseases / drug therapy,  pathology*,  radiography
Blister / etiology*,  physiopathology,  radiography
Forced Expiratory Volume
Immunosuppressive Agents / therapeutic use
Lung Diseases / etiology*,  physiopathology,  radiography
Middle Aged
Monocytes / pathology
Prednisolone / therapeutic use
Pulmonary Alveoli / pathology
Sjogren's Syndrome / drug therapy,  pathology*,  radiography
Tomography, X-Ray Computed
Reg. No./Substance:
0/Immunosuppressive Agents; 50-24-8/Prednisolone
Comment In:
Intern Med. 2002 Feb;41(2):73-4   [PMID:  11868609 ]

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