Document Detail

Two cases of subfoveal choroidal neovascularization with tubulointerstitial nephritis and uveitis syndrome.
MedLine Citation:
PMID:  23335312     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Tubulointerstitial nephritis and uveitis (TINU) syndrome usually shows anterior segment intraocular inflammation, but severe posterior segment intraocular inflammation is rarely observed. We report 2 children with TINU syndrome complicated by subfoveal choroidal neovascularization (CNV).
METHODS: Case reports.
RESULTS: Patients were a 12-year-old girl and a 12-year-old boy diagnosed with probable TINU syndrome on the basis of typical ocular findings and high value of urinary β2 microglobulin even though renal biopsy was not performed. The girl showed development of CNV with subretinal macular hemorrhage along with the exacerbation of anterior chamber inflammation in her left eye. Subretinal macular hemorrhage recurred frequently even with oral prednisolone; therefore, intravitreal injection of bevacizumab (IVB) was performed. After IVB, the subretinal proliferative tissue shrunk and subretinal hemorrhage has not recurred for 5 years. The boy showed subretinal hemorrhage from CNV with severe anterior chamber inflammation in his left eye. With oral prednisolone, anterior chamber inflammation and subretinal hemorrhage disappeared, but shrunken subretinal fibrosis in the macula remained. Final visual acuity was poor due to residual subretinal fibrosis in both cases.
CONCLUSIONS: Tubulointerstitial nephritis and uveitis syndrome has a potential to develop CNV that leads to severe visual loss; therefore, prompt anti-inflammatory therapy is required, and IVB should be regarded as a potential choice of treatment.
Yuko Takemoto; Kenichi Namba; Kazuomi Mizuuchi; Shigeaki Ohno; Susumu Ishida
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  European journal of ophthalmology     Volume:  23     ISSN:  1724-6016     ISO Abbreviation:  Eur J Ophthalmol     Publication Date:    2013 Mar-Apr
Date Detail:
Created Date:  2013-03-13     Completed Date:  2013-05-24     Revised Date:  2013-05-27    
Medline Journal Info:
Nlm Unique ID:  9110772     Medline TA:  Eur J Ophthalmol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  255-7     Citation Subset:  IM    
Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Angiogenesis Inhibitors / therapeutic use
Antibodies, Monoclonal, Humanized / therapeutic use
Choroidal Neovascularization / diagnosis,  drug therapy,  etiology*
Fluorescein Angiography
Fovea Centralis
Glucocorticoids / therapeutic use
Nephritis, Interstitial / complications*,  diagnosis,  drug therapy
Prednisolone / therapeutic use
Retinal Hemorrhage / diagnosis,  drug therapy,  etiology
Tomography, Optical Coherence
Uveitis / complications*,  diagnosis,  drug therapy
Vascular Endothelial Growth Factor A / antagonists & inhibitors
Visual Acuity
Reg. No./Substance:
0/Angiogenesis Inhibitors; 0/Antibodies, Monoclonal, Humanized; 0/Glucocorticoids; 0/VEGFA protein, human; 0/Vascular Endothelial Growth Factor A; 2S9ZZM9Q9V/bevacizumab; 50-24-8/Prednisolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Recurrent central serous chorioretinopathy after peripheral retinal laser photocoagulation: a case r...
Next Document:  Evaluation of corneal elevation in eyes with subclinical keratoconus and keratoconus using Galilei d...