Document Detail

Two cases of primary biliary cirrhosis complicated by acute leukemia.
MedLine Citation:
PMID:  17473489     Owner:  NLM     Status:  MEDLINE    
Case 1 was a 43-year-old woman, who was diagnosed as having PBC. After one month, she was hospitalized owing to sudden temporary unconsciousness. She was diagnosed as having acute lymphoid leukemia (ALL) by bone marrow examination. Chemotherapy was done, but she died after 6 months. Case 2 was a 54-year-old woman, who was diagnosed as having PBC with CREST syndrome. Seven years later, she was diagnosed as having acute promyelocytic leukemia (APL) by bone marrow examination. Chemotherapy was continued, and her symptoms are at present, stable. To date, there have been no reports of PBC complicated by acute leukemia.
Hironobu Saito; Kyoko Monoe; Yukiko Kanno; Atsushi Takahashi; Tsuyoshi Rai; Atsushi Irisawa; Hiromasa Ohira
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2007-05-01
Journal Detail:
Title:  Internal medicine (Tokyo, Japan)     Volume:  46     ISSN:  1349-7235     ISO Abbreviation:  Intern. Med.     Publication Date:  2007  
Date Detail:
Created Date:  2007-05-02     Completed Date:  2007-05-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9204241     Medline TA:  Intern Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  561-3     Citation Subset:  IM    
Department of Internal Medicine II, Fukushima Medical University School of Medicine, Fukushima, Japan.
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MeSH Terms
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Blotting, Western
CREST Syndrome / complications
Dihydrolipoyllysine-Residue Acetyltransferase / metabolism
Fatal Outcome
Leukemia, Promyelocytic, Acute / complications*,  drug therapy
Liver / pathology
Liver Cirrhosis, Biliary / complications*,  enzymology,  pathology
Middle Aged
Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications*,  drug therapy
Reg. No./Substance:
EC Acetyltransferase

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