Document Detail


Two cases of ischemia associated with subthalamic nucleus stimulator implantation for advanced Parkinson's disease.
MedLine Citation:
PMID:  16721751     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Deep brain stimulation is generally a safe and effective method of alleviating motor impairment in advanced-stage Parkinson's disease patients. However, adverse events of surgery have been noted, such as hemorrhage, infection, seizures, and device failure. In this report, we describe 2 cases of the unusual adverse event of ischemia associated with subthalamic nucleus stimulator implantation. We present the intraoperative neurological symptoms, microelectrode recording data, imaging findings, and other correlated events. In the first case, the clinical effects of ischemia were evident intraoperatively and coincided with silence during microelectrode recording from the ischemic region. In the second case, the timing of the ischemic event could not be determined precisely but also was associated with a difficult mapping. Subcortical ischemia may be an underrecognized event that confounds neurophysiological mapping of deep brain structures and affects clinical outcomes.
Authors:
Kevin E Novak; Emmanuel K Nenonene; Lawrence P Bernstein; Sandra Vergenz; Gina Medalle; Jordan M Prager; Theodore W Eller; Jeffrey W Cozzens; Michael Rezak
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Movement disorders : official journal of the Movement Disorder Society     Volume:  21     ISSN:  0885-3185     ISO Abbreviation:  Mov. Disord.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-09-27     Completed Date:  2007-02-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8610688     Medline TA:  Mov Disord     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1477-83     Citation Subset:  IM    
Copyright Information:
(c) 2006 Movement Disorder Society.
Affiliation:
Department of Neurology, at Evanston Northwestern Healthcare, Evanston, Illinois, USA.
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MeSH Terms
Descriptor/Qualifier:
Aged
Caudate Nucleus / blood supply
Cerebral Infarction / diagnosis,  etiology*,  physiopathology
Deep Brain Stimulation / adverse effects*
Diffusion Magnetic Resonance Imaging
Dominance, Cerebral / physiology
Electrodes, Implanted / adverse effects*
Female
Humans
Image Processing, Computer-Assisted
Male
Microelectrodes
Neurons / physiology
Parkinson Disease / physiopathology,  rehabilitation*
Risk Factors
Stereotaxic Techniques
Subthalamic Nucleus / physiopathology*
Surgery, Computer-Assisted
Thalamic Diseases / diagnosis,  etiology*,  physiopathology
Tomography, X-Ray Computed

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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