| Two cases of ischemia associated with subthalamic nucleus stimulator implantation for advanced Parkinson's disease. | |
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MedLine Citation:
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PMID: 16721751 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Deep brain stimulation is generally a safe and effective method of alleviating motor impairment in advanced-stage Parkinson's disease patients. However, adverse events of surgery have been noted, such as hemorrhage, infection, seizures, and device failure. In this report, we describe 2 cases of the unusual adverse event of ischemia associated with subthalamic nucleus stimulator implantation. We present the intraoperative neurological symptoms, microelectrode recording data, imaging findings, and other correlated events. In the first case, the clinical effects of ischemia were evident intraoperatively and coincided with silence during microelectrode recording from the ischemic region. In the second case, the timing of the ischemic event could not be determined precisely but also was associated with a difficult mapping. Subcortical ischemia may be an underrecognized event that confounds neurophysiological mapping of deep brain structures and affects clinical outcomes. |
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Authors:
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Kevin E Novak; Emmanuel K Nenonene; Lawrence P Bernstein; Sandra Vergenz; Gina Medalle; Jordan M Prager; Theodore W Eller; Jeffrey W Cozzens; Michael Rezak |
Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Movement disorders : official journal of the Movement Disorder Society Volume: 21 ISSN: 0885-3185 ISO Abbreviation: Mov. Disord. Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2006-09-27 Completed Date: 2007-02-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8610688 Medline TA: Mov Disord Country: United States |
Other Details:
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Languages: eng Pagination: 1477-83 Citation Subset: IM |
Copyright Information:
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(c) 2006 Movement Disorder Society. |
Affiliation:
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Department of Neurology, at Evanston Northwestern Healthcare, Evanston, Illinois, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Caudate Nucleus / blood supply Cerebral Infarction / diagnosis, etiology*, physiopathology Deep Brain Stimulation / adverse effects* Diffusion Magnetic Resonance Imaging Dominance, Cerebral / physiology Electrodes, Implanted / adverse effects* Female Humans Image Processing, Computer-Assisted Male Microelectrodes Neurons / physiology Parkinson Disease / physiopathology, rehabilitation* Risk Factors Stereotaxic Techniques Subthalamic Nucleus / physiopathology* Surgery, Computer-Assisted Thalamic Diseases / diagnosis, etiology*, physiopathology Tomography, X-Ray Computed |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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