Document Detail


Two cases of fatal amlodipine overdose.
MedLine Citation:
PMID:  16839474     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Two fatal overdoses of the calcium channel blocker amlodipine are described. Postmortem samples were screened for volatiles and therapeutic and abused drugs. Amlodipine was measured by liquid chromatography-atmospheric pressure photoionization-mass spectrometry. The heart blood amlodipine concentrations for the two cases were 2.4 and 0.95 mg/L, and amlodipine was quantified in all other tissues. In the first case, venlafaxine and norvenlafaxine were also found, and the angiotensin receptor antagonist olmesartan was tentatively identified. The concentrations of amlodipine are compared with previously reported fatal and nonfatal overdoses. The medical examiners ruled in both cases that the manner of death was suicide and the causes of death were mixed drug intoxication and amlodipine intoxication.
Authors:
Jason H Sklerov; Barry Levine; Kathleen M Ingwersen; Patricia A Aronica-Pollack; David Fowler
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of analytical toxicology     Volume:  30     ISSN:  0146-4760     ISO Abbreviation:  J Anal Toxicol     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-07-14     Completed Date:  2006-11-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7705085     Medline TA:  J Anal Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  346-51     Citation Subset:  IM    
Affiliation:
Division of Forensic Toxicology, Office of the Armed Forces Medical Examiner, 1413 Research Blvd., Rockville, Maryland 20850, USA. Jason.Sklerov@dc.gov
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Amlodipine / blood,  poisoning*,  urine
Antihypertensive Agents / blood,  poisoning*,  urine
Calcium Channel Blockers / blood,  poisoning*,  urine
Female
Gastrointestinal Contents / chemistry
Humans
Hypertension / drug therapy
Male
Overdose
Suicide
Tissue Distribution
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 0/Calcium Channel Blockers; 88150-42-9/Amlodipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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