Document Detail

Two cases of chlorinated hydrocarbon-associated myocardial ischemia.
MedLine Citation:
PMID:  9311088     Owner:  NLM     Status:  MEDLINE    
Chlorinated hydrocarbons are well known to produce ventricular arrhythmias because of myocardial sensitization to endogenous catecholamines, but cases of myocardial ischemia have not been described frequently. We report 2 cases of myocardial ischemia after exposure to chlorinated hydrocarbons. The first patient developed an asymptomatic myocardial infarction after inhalation of 1,1,1-trichloroethane at work. It is believed that 1,1,1-trichloroethane produced a coronary spasm that was sufficient to cause myocardial necrosis in the presence of coronary vessels already compromised by atherosclerosis. The second patient developed a reversible symptomatic myocardial ischemia of 4 h duration after chloral hydrate overdose. The evolution in both patients was favorable. Exposure to chlorinated hydrocarbons can be associated with myocardial ischemia particularly if the coronary circulation is already compromised.
B Bailey; R Loebstein; C Lai; M A McGuigan
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Veterinary and human toxicology     Volume:  39     ISSN:  0145-6296     ISO Abbreviation:  Vet Hum Toxicol     Publication Date:  1997 Oct 
Date Detail:
Created Date:  1997-12-23     Completed Date:  1997-12-23     Revised Date:  2013-01-24    
Medline Journal Info:
Nlm Unique ID:  7704194     Medline TA:  Vet Hum Toxicol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  298-301     Citation Subset:  IM    
Department of Pediatrics, Hospital for Sick Children, Toronto, Canada.
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MeSH Terms
Chloral Hydrate / adverse effects*
Coronary Disease / complications
Drug Overdose
Electrocardiography / drug effects
Hypnotics and Sedatives / adverse effects*
Myocardial Infarction / chemically induced*
Myocardial Ischemia / chemically induced*,  diagnosis
Occupational Exposure / adverse effects*
Solvents / adverse effects*
Suicide, Attempted
Trichloroethanes / adverse effects*
Reg. No./Substance:
0/Hypnotics and Sedatives; 0/Solvents; 0/Trichloroethanes; 113C650IR1/1,1,1-trichloroethane; 302-17-0/Chloral Hydrate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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