Document Detail


Two cases of chlorinated hydrocarbon-associated myocardial ischemia.
MedLine Citation:
PMID:  9311088     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Chlorinated hydrocarbons are well known to produce ventricular arrhythmias because of myocardial sensitization to endogenous catecholamines, but cases of myocardial ischemia have not been described frequently. We report 2 cases of myocardial ischemia after exposure to chlorinated hydrocarbons. The first patient developed an asymptomatic myocardial infarction after inhalation of 1,1,1-trichloroethane at work. It is believed that 1,1,1-trichloroethane produced a coronary spasm that was sufficient to cause myocardial necrosis in the presence of coronary vessels already compromised by atherosclerosis. The second patient developed a reversible symptomatic myocardial ischemia of 4 h duration after chloral hydrate overdose. The evolution in both patients was favorable. Exposure to chlorinated hydrocarbons can be associated with myocardial ischemia particularly if the coronary circulation is already compromised.
Authors:
B Bailey; R Loebstein; C Lai; M A McGuigan
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Veterinary and human toxicology     Volume:  39     ISSN:  0145-6296     ISO Abbreviation:  Vet Hum Toxicol     Publication Date:  1997 Oct 
Date Detail:
Created Date:  1997-12-23     Completed Date:  1997-12-23     Revised Date:  2013-01-24    
Medline Journal Info:
Nlm Unique ID:  7704194     Medline TA:  Vet Hum Toxicol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  298-301     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Hospital for Sick Children, Toronto, Canada.
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MeSH Terms
Descriptor/Qualifier:
Adult
Chloral Hydrate / adverse effects*
Coronary Disease / complications
Drug Overdose
Electrocardiography / drug effects
Female
Humans
Hypnotics and Sedatives / adverse effects*
Myocardial Infarction / chemically induced*
Myocardial Ischemia / chemically induced*,  diagnosis
Occupational Exposure / adverse effects*
Solvents / adverse effects*
Suicide, Attempted
Trichloroethanes / adverse effects*
Chemical
Reg. No./Substance:
0/Hypnotics and Sedatives; 0/Solvents; 0/Trichloroethanes; 113C650IR1/1,1,1-trichloroethane; 302-17-0/Chloral Hydrate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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