| Two cases of chlorinated hydrocarbon-associated myocardial ischemia. | |
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MedLine Citation:
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PMID: 9311088 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chlorinated hydrocarbons are well known to produce ventricular arrhythmias because of myocardial sensitization to endogenous catecholamines, but cases of myocardial ischemia have not been described frequently. We report 2 cases of myocardial ischemia after exposure to chlorinated hydrocarbons. The first patient developed an asymptomatic myocardial infarction after inhalation of 1,1,1-trichloroethane at work. It is believed that 1,1,1-trichloroethane produced a coronary spasm that was sufficient to cause myocardial necrosis in the presence of coronary vessels already compromised by atherosclerosis. The second patient developed a reversible symptomatic myocardial ischemia of 4 h duration after chloral hydrate overdose. The evolution in both patients was favorable. Exposure to chlorinated hydrocarbons can be associated with myocardial ischemia particularly if the coronary circulation is already compromised. |
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Authors:
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B Bailey; R Loebstein; C Lai; M A McGuigan |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Veterinary and human toxicology Volume: 39 ISSN: 0145-6296 ISO Abbreviation: Vet Hum Toxicol Publication Date: 1997 Oct |
Date Detail:
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Created Date: 1997-12-23 Completed Date: 1997-12-23 Revised Date: 2013-01-24 |
Medline Journal Info:
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Nlm Unique ID: 7704194 Medline TA: Vet Hum Toxicol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 298-301 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Hospital for Sick Children, Toronto, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Chloral Hydrate / adverse effects* Coronary Disease / complications Drug Overdose Electrocardiography / drug effects Female Humans Hypnotics and Sedatives / adverse effects* Myocardial Infarction / chemically induced* Myocardial Ischemia / chemically induced*, diagnosis Occupational Exposure / adverse effects* Solvents / adverse effects* Suicide, Attempted Trichloroethanes / adverse effects* |
| Chemical | |
Reg. No./Substance:
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0/Hypnotics and Sedatives; 0/Solvents; 0/Trichloroethanes; 113C650IR1/1,1,1-trichloroethane; 302-17-0/Chloral Hydrate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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