Document Detail

Two cases of bradyarrhythmia and hypotension after extradural injections in dogs.
MedLine Citation:
PMID:  18282259     Owner:  NLM     Status:  MEDLINE    
OBSERVATIONS: Two healthy obese, seven-year-old, female Rottweilers weighing 40 and 57 kg were submitted for cranial cruciate repair. They were premedicated with intravenous methadone (0.1 mg kg(-1)) and acepromazine (0.01 and 0.02 mg kg(-1)). Anesthesia was induced with propofol (3.6 and 2.5 mg kg(-1)) and maintained with isoflurane in oxygen using a circle breathing system. The dogs were placed in sternal recumbency and epidural injection of lidocaine/bupivacaine or lidocaine/bupivacaine/morphine (0.2 mL/kg, 8 and 11 mL) was carried out over 1.5 and 4 minutes. Epidural pressures were 79 and 72 mmHg at the end of the injections. The first dog's heart rate decreased from 80 to 65 beats minute(-1) with a second degree atrioventricular (AV) block. The arterial pressure decreased from 100 to 50 mmHg. These responded to atropine (0.01 mg kg(-1) IV). The second dog's heart rate decreased from 120 to 60 beats minute(-1) while arterial pressure decreased from 72 to 38 mmHg. No treatment was given and heart rate and arterial blood pressure returned to acceptable ranges.
CONCLUSIONS: These cases suggest that large increases in epidural pressure may cause significant cardiovascular effects. This may be avoided by using lower volumes and discontinuing injection if significant back pressure is detected.
Isabelle Iff; Yves Moens
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2008-02-18
Journal Detail:
Title:  Veterinary anaesthesia and analgesia     Volume:  35     ISSN:  1467-2995     ISO Abbreviation:  Vet Anaesth Analg     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-05-07     Completed Date:  2008-10-27     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  100956422     Medline TA:  Vet Anaesth Analg     Country:  England    
Other Details:
Languages:  eng     Pagination:  265-9     Citation Subset:  IM    
Clinic of Anaesthesiology and Perioperative Intensive Care, Clinical Department of Small Animals and Horses, Veterinary University, Vienna, Austria.
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MeSH Terms
Analgesics / administration & dosage,  adverse effects*
Bradycardia / chemically induced*
Bupivacaine / administration & dosage,  adverse effects*
Dog Diseases / chemically induced*
Hypotension / chemically induced
Injections, Epidural
Lidocaine / administration & dosage,  adverse effects*
Morphine / administration & dosage,  adverse effects*
Reg. No./Substance:
0/Analgesics; 137-58-6/Lidocaine; 2180-92-9/Bupivacaine; 57-27-2/Morphine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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