Document Detail

Two cases of autoimmune hemolytic anemia secondary to brucellosis: a review of hemolytic disorders in patients with brucellosis.
MedLine Citation:
PMID:  24881740     Owner:  NLM     Status:  In-Data-Review    
Brucellosis is a worldwide zoonotic disease associated with hemolytic complications, including thrombotic microangiopathy (TMA) and hemolytic anemia. Autoimmune hemolytic anemia (AIHA) is a rare clinical presentation of this disease. In this report, we describe the cases of two patients with brucellosis who presented with Coombs-positive AIHA. We also include a review of the literature on the hemolytic complications of brucellosis. Both patients were successfully treated with a combination of doxycycline and rifampicin in addition to steroids. In the medical literature, there are several cases of TMA associated with brucellosis, although only a few cases of Coombs test-positive AIHA have been reported. Antibiotic therapy is the mainstay of treatment, and the selection of antibiotics and duration of treatment do not differ between brucellosis patients with and without hemolysis. Although rare, the potential for brucellosis should always be kept in mind in patients who present with hemolysis, especially those living in areas where brucellosis is endemic.
Ahmet Emre Eskazan; Mehmet Sinan Dal; Safak Kaya; Tuba Dal; Orhan Ayyildiz; Teoman Soysal
Publication Detail:
Type:  Journal Article     Date:  2014-06-01
Journal Detail:
Title:  Internal medicine (Tokyo, Japan)     Volume:  53     ISSN:  1349-7235     ISO Abbreviation:  Intern. Med.     Publication Date:  2014  
Date Detail:
Created Date:  2014-06-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9204241     Medline TA:  Intern Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1153-8     Citation Subset:  IM    
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