Document Detail


Two cases of aspergillus endocarditis in non neutropenic children on chemotherapy for acute lymphoblastic leukaemia.
MedLine Citation:
PMID:  22184529     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Fungal endocarditis (FE) is a rare complication in immunocompromised patients which is difficult to diagnose and has been characterized by excessive mortality (> 50%) and morbidity, regardless of treatment. The lack of clinical trials due to the small number of cases contributes further to a poor outcome. In our two cases of aspergilllus endocarditis we reviewed the clinical features, echocardiographic findings, microbiologic data, treatment, and outcome of these 2 cases and provide a current characterization of the syndrome. In this paper we have demonstrated the diversity of presentation of a critical fungal infection in immunocompromised but non neutropenic paediatric patients. The prompt diagnosis and initiation of treatment is crucial for a favourable outcome along with the use of double antifungal treatment with liposomal amphotericin and voriconazole initially which could be later switched to oral voriconazole with a good tissue penetration. Histological samples as well as radiological evidence and echocardiograms should be reviewed by experienced clinicians in order to aid diagnosis and promptly initiate treatment for these patients in order to achieve a favourable outcome.
Authors:
Emmanouil Nikolousis; Mark Velangi
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Publication Detail:
Type:  Journal Article     Date:  2011-06-30
Journal Detail:
Title:  Hematology reports     Volume:  3     ISSN:  2038-8330     ISO Abbreviation:  Hematol Rep     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-12-20     Completed Date:  2012-10-02     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101556723     Medline TA:  Hematol Rep     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  e7     Citation Subset:  -    
Affiliation:
Haematology department, Birmingham Childrens Hospital, United Kingdom.
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