Document Detail


Two cases of aspergillus endocarditis in non neutropenic children on chemotherapy for acute lymphoblastic leukaemia.
MedLine Citation:
PMID:  22184529     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Fungal endocarditis (FE) is a rare complication in immunocompromised patients which is difficult to diagnose and has been characterized by excessive mortality (> 50%) and morbidity, regardless of treatment. The lack of clinical trials due to the small number of cases contributes further to a poor outcome. In our two cases of aspergilllus endocarditis we reviewed the clinical features, echocardiographic findings, microbiologic data, treatment, and outcome of these 2 cases and provide a current characterization of the syndrome. In this paper we have demonstrated the diversity of presentation of a critical fungal infection in immunocompromised but non neutropenic paediatric patients. The prompt diagnosis and initiation of treatment is crucial for a favourable outcome along with the use of double antifungal treatment with liposomal amphotericin and voriconazole initially which could be later switched to oral voriconazole with a good tissue penetration. Histological samples as well as radiological evidence and echocardiograms should be reviewed by experienced clinicians in order to aid diagnosis and promptly initiate treatment for these patients in order to achieve a favourable outcome.
Authors:
Emmanouil Nikolousis; Mark Velangi
Related Documents :
24629759 - Diffuse interstitial lung disease as a first manifestation of waldenström's macroglobu...
23120689 - Rare impacted foreign bodies of larynx.
15641009 - Distal symmetrical polyneuropathy: a definition for clinical research. a report of the ...
25349549 - Pharmacist perception and use of uptodate®.
20511169 - Intracranial multifocal dural involvement in multiple myeloma: case report and review o...
18848389 - Leber's optic neuropathy associated with disseminated white matter disease: a case repo...
22684139 - Urethral duplication: case report and literature review.
9749889 - Pseudomyxoma peritonei--a heterogenous disease.
2768579 - Acral persistent papular mucinosis.
Publication Detail:
Type:  Journal Article     Date:  2011-06-30
Journal Detail:
Title:  Hematology reports     Volume:  3     ISSN:  2038-8330     ISO Abbreviation:  Hematol Rep     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-12-20     Completed Date:  2012-10-02     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101556723     Medline TA:  Hematol Rep     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  e7     Citation Subset:  -    
Affiliation:
Haematology department, Birmingham Childrens Hospital, United Kingdom.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Double cord blood transplantation: co-operation or competition?
Next Document:  Powered bone marrow biopsy procedures produce larger core specimens, with less pain, in less time th...