Document Detail

Two cases of acute myeloblastic leukemia evolving from aplastic anemia.
MedLine Citation:
PMID:  12841385     Owner:  NLM     Status:  MEDLINE    
Two cases of acute myeloblastic leukemia (AML) evolving from aplastic anemia are presented. The first case was diagnosed 18 years ago, and treatment with bolus methylprednisolone, prednisolone, and androgens resulted in partial hematological response. Severe pancytopenia recurred, and AML M0 by French-American-British classification developed. The second case was diagnosed 7 years ago. The patient had HLA DRB1*1501, and treatment with granulocyte colony-stimulating factor (G-CSF), cyclosporine, and methenolone resulted in complete hematological response. Thrombocytopenia recurred and did not respond to cyclosporine and methenolone or to later treatment with antithymocyte globulin, and AML M1 developed. Cytogenetic studies demonstrated 7q- in the first patient and +8 in the second patient. No mutations of N-ras or p53 were observed in either patient. These patients were treated with cytosine arabinoside, aclacinomycin, and G-CSF (CAG) chemotherapy, and the number of leukemic cells decreased substantially. However, pancytopenia after CAG chemotherapy persisted, and the first patient died of pneumonia and the second patient of cerebral hemorrhage.
Akihiko Taguchi; Takayuki Tominaga; Yoshitaka Nakamori; Mutsuko Miyazaki; Kenji Shinohara
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  International journal of hematology     Volume:  77     ISSN:  0925-5710     ISO Abbreviation:  Int. J. Hematol.     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-07-04     Completed Date:  2003-10-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9111627     Medline TA:  Int J Hematol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  471-5     Citation Subset:  IM    
Division of Hematology, Department of Medicine, Yamaguchi Prefecture Central Hospital, Hofu, Japan.
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MeSH Terms
Anemia, Aplastic / drug therapy,  pathology*
Cytogenetic Analysis
DNA Mutational Analysis
Fatal Outcome
Granulocyte Colony-Stimulating Factor / therapeutic use
HLA-DR Antigens / analysis
Hormones / therapeutic use
Immunosuppressive Agents / therapeutic use
Leukemia, Myeloid, Acute / drug therapy,  etiology*,  genetics
Middle Aged
Pancytopenia / etiology
Reg. No./Substance:
0/HLA-DR Antigens; 0/Hormones; 0/Immunosuppressive Agents; 143011-72-7/Granulocyte Colony-Stimulating Factor

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