| Two cases of acute myeloblastic leukemia evolving from aplastic anemia. | |
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MedLine Citation:
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PMID: 12841385 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Two cases of acute myeloblastic leukemia (AML) evolving from aplastic anemia are presented. The first case was diagnosed 18 years ago, and treatment with bolus methylprednisolone, prednisolone, and androgens resulted in partial hematological response. Severe pancytopenia recurred, and AML M0 by French-American-British classification developed. The second case was diagnosed 7 years ago. The patient had HLA DRB1*1501, and treatment with granulocyte colony-stimulating factor (G-CSF), cyclosporine, and methenolone resulted in complete hematological response. Thrombocytopenia recurred and did not respond to cyclosporine and methenolone or to later treatment with antithymocyte globulin, and AML M1 developed. Cytogenetic studies demonstrated 7q- in the first patient and +8 in the second patient. No mutations of N-ras or p53 were observed in either patient. These patients were treated with cytosine arabinoside, aclacinomycin, and G-CSF (CAG) chemotherapy, and the number of leukemic cells decreased substantially. However, pancytopenia after CAG chemotherapy persisted, and the first patient died of pneumonia and the second patient of cerebral hemorrhage. |
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Authors:
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Akihiko Taguchi; Takayuki Tominaga; Yoshitaka Nakamori; Mutsuko Miyazaki; Kenji Shinohara |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: International journal of hematology Volume: 77 ISSN: 0925-5710 ISO Abbreviation: Int. J. Hematol. Publication Date: 2003 Jun |
Date Detail:
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Created Date: 2003-07-04 Completed Date: 2003-10-29 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9111627 Medline TA: Int J Hematol Country: Ireland |
Other Details:
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Languages: eng Pagination: 471-5 Citation Subset: IM |
Affiliation:
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Division of Hematology, Department of Medicine, Yamaguchi Prefecture Central Hospital, Hofu, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anemia, Aplastic
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drug therapy,
pathology* Child Cytogenetic Analysis DNA Mutational Analysis Fatal Outcome Female Granulocyte Colony-Stimulating Factor / therapeutic use HLA-DR Antigens / analysis Hormones / therapeutic use Humans Immunosuppressive Agents / therapeutic use Leukemia, Myeloid, Acute / drug therapy, etiology*, genetics Male Middle Aged Pancytopenia / etiology |
| Chemical | |
Reg. No./Substance:
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0/HLA-DR Antigens; 0/Hormones; 0/Immunosuppressive Agents; 143011-72-7/Granulocyte Colony-Stimulating Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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