Document Detail


Two biochemical markers effectively used to separate smokeless tobacco users from smokers and nonusers.
MedLine Citation:
PMID:  7481979     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Data from asbestos workers were used to devise a cutpoint classifier to identify subjects as Nonuser (non-tobacco user), Smokeless (exclusive smokeless tobacco user), and Smoker (ignited tobacco user). In some clinical trials and smoking cessation programs, Smokeless should be separated from Smoker. One therefore needs a marker for smoke exposure, such as thiocyanate, since nicotine levels, as measured by cotinine, could be similar in both groups. Levels of cotinine (ng/mL) and thiocyanate (mumol/L) levels (mean +/- SD) were, respectively: 320.9 +/- 201.1 and 145.9 +/- 63.7 for the Smoker group; 339.1 +/- 327.5 and 32.0 +/- 16.9 for the Smokeless group; and 0.6 +/- 2.6 and 58.2 +/- 33.2 for the Nonuser group. For Nonuser, Smokeless, and Smoker, respectively, the self-reported status was 45.1%, 10.8%, and 44.1%, which was adjusted to 42.2%, 11.6%, and 46.2%; the classifier yielded sensitivities of 100%, 76.1%, and 92.2%; specificities of 96.1%, 97.6%, and 96.4%; and predictive values of 94.9%, 80.6%, and 95.6%. The classifier successfully identified Nonusers, separated Smokeless from Smoker, and determined the prevalence of false reports in our cohort.
Authors:
D B Holiday; J W McLarty; R H Yanagihara; L Riley; S B Shepherd
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Southern medical journal     Volume:  88     ISSN:  0038-4348     ISO Abbreviation:  South. Med. J.     Publication Date:  1995 Nov 
Date Detail:
Created Date:  1995-12-01     Completed Date:  1995-12-01     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0404522     Medline TA:  South Med J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1107-13     Citation Subset:  AIM; IM    
Affiliation:
Department of Epidemiology/Biomathematics, University of Texas Health Center at Tyler 75710, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Asbestos
Cohort Studies
Cotinine / blood*
Discriminant Analysis
Female
Forecasting
Health Behavior
Humans
Male
Middle Aged
Occupational Exposure
Plants, Toxic*
Predictive Value of Tests
Prevalence
Probability
Sensitivity and Specificity
Smoking / blood*
Thiocyanates / blood*
Tobacco, Smokeless*
Grant Support
ID/Acronym/Agency:
CA-34290/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Thiocyanates; 1332-21-4/Asbestos; 302-04-5/thiocyanate; 486-56-6/Cotinine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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