Document Detail


Two auronols from Pseudolarix amabilis.
MedLine Citation:
PMID:  10346966     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Two new auronols, amaronols A (1) and B (2), were isolated from the bark of Pseudolarix amabilis, along with pseudolaric acid B (3), pseudolaric acid C (4), demethoxydeacetoxy-pseudolaric acid B (5), pseudolaric acid B-beta-D-glucoside (6), pseudolaric acid A-beta-D-glucoside (7), and myricetin (8). The structures of amaronols A and B were established by spectral data interpretation as 2,4,6-trihydroxy-2-[(3',4',5'-trihydroxyphenyl) methyl]-3(2H)-benzofuranone and 2,4,6-trihydroxy-2-[(3', 5'-dihydroxy-4'-methoxyphenyl) methyl]-3(2H)-benzofuranone, respectively. Antimicrobial testing results of the eight compounds indicated that only pseudolaric acid B was active against Candida albicans (MIC, 3.125 microg/mL; MFC, 6.25 microg/mL), while myricetin was marginally active against Trichophyton mentagrophytes (MIC, 50 microg/mL).
Authors:
X C Li; H N ElSohly; A C Nimrod; A M Clark
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of natural products     Volume:  62     ISSN:  0163-3864     ISO Abbreviation:  J. Nat. Prod.     Publication Date:  1999 May 
Date Detail:
Created Date:  1999-07-29     Completed Date:  1999-07-29     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7906882     Medline TA:  J Nat Prod     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  767-9     Citation Subset:  IM    
Affiliation:
National Center for the Development of Natural Products, Research Institute of Pharmaceutical Sciences and Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, University, Mississippi 38677, USA.
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MeSH Terms
Descriptor/Qualifier:
Antifungal Agents / chemistry,  isolation & purification,  pharmacology*
Benzofurans / chemistry,  isolation & purification,  pharmacology*
Candida albicans / drug effects
Chromatography, High Pressure Liquid
Drugs, Chinese Herbal / chemistry*
Gymnosperms / chemistry*
Magnetic Resonance Spectroscopy
Mass Spectrometry
Microbial Sensitivity Tests
Phenols / chemistry,  isolation & purification,  pharmacology*
Spectrophotometry, Ultraviolet
Trichophyton / drug effects
Grant Support
ID/Acronym/Agency:
AI 27094/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Antifungal Agents; 0/Benzofurans; 0/Drugs, Chinese Herbal; 0/Phenols; 0/amaronol A; 0/amaronol B

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