Document Detail

Two-Year Subjective, Objective, Quality of Life, and Endoscopic Follow-up After Laparoscopic Nissen-Rossetti in Patients With Columnar-lined Esophagus.
MedLine Citation:
PMID:  23751995     Owner:  NLM     Status:  In-Data-Review    
INTRODUCTION: : Barrett esophagus (BE) is a complication of gastroesophageal reflux disease. We wish to determine the effects of surgery on the histology of the esophageal mucosa and evaluate Quality of Life.
MATERIALS AND METHODS: : Twenty-seven patients with columnar-lined esophagus (CLE) metaplasia underwent laparoscopic Nissen-Rossetti fundoplication. Patients were submitted to close follow-up.
RESULTS: : One patient voluntarily left follow-up after surgery. CLE was still present in 18 patients (66.6%); no patient developed dysplasia or esophageal adenocarcinoma. Two patients with gastric metaplasia and 1 patient with intestinal metaplasia had regression at 12 and 24 months after surgery (11.1%). DeMeester and Johnson score decreased from 38.69 (SD±51.44) to 11.99 (SD±18.08) at 6 months, 12.69 (SD±12.91) at 12 months, and it was 11.38 (SD±6.43) at 24 months. Preoperative gastroesophageal reflux disease-health related quality of life was 19.90 (SD±18.54), 9.80 (SD±8.77) at 6 months, 9.57 (SD±9.14) at 12 months, and 11.53 (SD±6.48) at 24 months. Short form-36 measurement showed significant improvement.
CONCLUSIONS: : Management of CLE requires multidisciplinary approach. Medical therapy does not prevent biliary reflux into the esophagus. Surgical therapy is effective and long lasting. It should be performed by experienced surgical teams.
Salvatore Marano; Stefano Mattacchione; Barbara Luongo; Valentina Mingarelli; Giuseppe Campagna; Filippo Tosato
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Surgical laparoscopy, endoscopy & percutaneous techniques     Volume:  23     ISSN:  1534-4908     ISO Abbreviation:  Surg Laparosc Endosc Percutan Tech     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-06-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888751     Medline TA:  Surg Laparosc Endosc Percutan Tech     Country:  United States    
Other Details:
Languages:  eng     Pagination:  292-8     Citation Subset:  IM    
*Referral Center for the Surgical Treatment of Gastroesophageal Reflux Diseases, Department of Surgery "F. Durante," Policlinico "Umberto I" †Department of Internal Medicine and Medical Specialities, University of Rome, "Sapienza", Rome, Italy.
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