Document Detail

Two-year clinical outcome after abciximab-coated stent implantation in patients with coronary artery disease.
MedLine Citation:
PMID:  20103970     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Despite abciximab-coated stents having an inhibitory effect on coronary artery restenosis, the medium-term clinical outcome is unknown.
METHODS AND RESULTS: This prospective, randomized study compared the effects of the abciximab-coated stent, which was implanted in 95 patients, with those of control bare metal stents (BMS) implanted in 93 patients for de novo coronary lesions. Stent implantation was performed without any complications associated with the procedure. The 6-month intravascular ultrasound analysis showed that the area of neointimal hyperplasia was significantly smaller in the abciximab-coated stent group compared with the control stent group (+2.0+/-1.6 mm(2) vs +3.4+/-1.7 mm(2), P=0.001). However, at 2-year clinical follow up, there were no statistically significant differences in the incidences of total major adverse cardiac events (16% vs 24%, P=0.19) and cardiac death (0% vs 1.1%, P=0.3), target vessel revascularization (16% vs 21%, P=0.4) or non-fatal myocardial infarction (0% vs 2.3%, P=0.16) in the abciximab-coated stent group compared with the control stent group.
CONCLUSIONS: Although abciximab-coated stents are safe and inhibit neointimal hyperplasia, they have no superiority over BMS in 2-year clinical outcome.
Sung Soo Kim; Young Joon Hong; Myung Ho Jeong; Weon Kim; Hyun-Kuk Kim; Jum Suk Ko; Min Goo Lee; Doo Sun Sim; Keun Ho Park; Nam Sik Yoon; Hyun Ju Yoon; Kye Hun Kim; Hyung Wook Park; Ju Han Kim; Youngkeun Ahn; Jeong Gwan Cho; Jong Chun Park; Sun-Jung Song; Dong Lyun Cho; Jung Chaee Kang
Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2010-01-26
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  74     ISSN:  1347-4820     ISO Abbreviation:  Circ. J.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-26     Completed Date:  2010-05-24     Revised Date:  2013-05-24    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  442-8     Citation Subset:  IM    
The Heart Center of Chonnam National University Hospital, Dong-gu, Gwangju 501-757, Korea.
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MeSH Terms
Angioplasty, Balloon, Coronary* / mortality
Antibodies, Monoclonal / therapeutic use*
Coronary Artery Disease / mortality,  therapy*,  ultrasonography
Coronary Restenosis / mortality,  prevention & control
Coronary Thrombosis / mortality,  prevention & control
Death, Sudden, Cardiac / epidemiology,  prevention & control
Disease-Free Survival
Drug-Eluting Stents* / statistics & numerical data
Follow-Up Studies
Immunoglobulin Fab Fragments / therapeutic use*
Kaplan-Meier Estimate
Middle Aged
Platelet Aggregation Inhibitors / therapeutic use*
Prospective Studies
Treatment Outcome
Ultrasonography, Interventional
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Immunoglobulin Fab Fragments; 0/Metals; 0/Platelet Aggregation Inhibitors; X85G7936GV/abciximab
Comment In:
Circ J. 2010 Mar;74(3):424-5   [PMID:  20145336 ]

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