| Two-Year Carcinogenicity Studies With the Oral Direct Thrombin Inhibitor Ximelagatran in the Rat and the Mouse. | |
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MedLine Citation:
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PMID: 22692977 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The results of 18 months mouse and 24 months rat carcinogenicity studies with the oral direct thrombin inhibitor ximelagatran are presented. In the mouse, gavage doses of ximelagatran up to 180 μmol/kg per d produced no neoplastic changes in any of the tissues examined. In the rat, gavage doses up to 240 μmol/kg per d produced multiple macroscopically detectable nodules in the pancreas, which are seen to be focal/multifocal acinar cell hyperplasia and focal/multifocal acinar cell adenoma upon histological evaluation. There were no other treatment-related effects on tumor incidence or distribution in the rat. The studies show a clear species difference in pancreatic effects between the rat and the mouse to long-term treatment with ximelagatran. |
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Authors:
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David B Stong; Stefan C Carlsson; Sivert Bjurström; Ronny Fransson-Steen; Guy Healing; Inger Skånberg |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-6-12 |
Journal Detail:
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Title: International journal of toxicology Volume: - ISSN: 1092-874X ISO Abbreviation: - Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-6-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9708436 Medline TA: Int J Toxicol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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AstraZeneca Pharmaceuticals LP, Sodertalje, Sweden. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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