Document Detail


Two-year analysis of efficacy and safety of deferasirox treatment for transfusional iron overload in sickle cell anemia patients.
MedLine Citation:
PMID:  22760067     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The efficacy and safety of a 2-year treatment with deferasirox was evaluated in 31 patients with sickle cell anemia and transfusional iron overload. At 24 months, there were significant decreases from baseline in mean serum ferritin (from 2,344.6 to 1,986.3 µg/l; p = 0.040) and in mean liver iron concentration (from 13.0 ± 5.4 to 9.3 ± 5.7 mg Fe/g dry weight; p < 0.001). Myocardial T2* values were normal (>20 ms) in all patients at baseline and did not change significantly over the course of the study. However, there was a significant improvement from baseline in left ventricular ejection fraction at 24 months (62.2-64.6%; p = 0.02). Deferasirox was generally well tolerated with no progressive increases in serum creatinine or renal failure observed. These data confirm that deferasirox is effective in reducing body iron burden in patients with sickle cell anemia and transfusional iron overload.
Authors:
Rodolfo Cancado; Maria Cristina A Olivato; Paula Bruniera; Gilberto Szarf; Roberto de Moraes Bastos; Murilo Rezende Melo; Carlos Chiattone
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Publication Detail:
Type:  Clinical Trial, Phase IV; Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-06-30
Journal Detail:
Title:  Acta haematologica     Volume:  128     ISSN:  1421-9662     ISO Abbreviation:  Acta Haematol.     Publication Date:  2012  
Date Detail:
Created Date:  2012-08-21     Completed Date:  2012-10-23     Revised Date:  2013-06-03    
Medline Journal Info:
Nlm Unique ID:  0141053     Medline TA:  Acta Haematol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  113-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 S. Karger AG, Basel.
Affiliation:
Department of Hematology/Oncology, Santa Casa Medical School, São Paulo, Brazil. rdcan@uol.com.br
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Anemia, Sickle Cell / drug therapy*
Benzoates / adverse effects,  therapeutic use*
Female
Humans
Iron Chelating Agents / adverse effects,  therapeutic use*
Iron Overload / drug therapy*
Male
Prospective Studies
Triazoles / adverse effects,  therapeutic use*
Young Adult
Chemical
Reg. No./Substance:
0/Benzoates; 0/Iron Chelating Agents; 0/Triazoles; V8G4MOF2V9/deferasirox

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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