| Two-way communication between endometrial stromal cells and monocytes. | |
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MedLine Citation:
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PMID: 19843877 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Immune system cells and cells of the endometrium have long been proposed to interact in both physiological and pathological processes. The current study was undertaken to examine communication between cultured monocytes and endometrial stromal cells and also to assess responses of endometrial stromal cells for treatment with estradiol (E) in the absence and presence of medroxyprogesterone acetate (P). A telomerase-immortalized human endometrial stromal cell (T-HESC) line and the U937 monocyte cell line were used. Telomerase-immortalized human endometrial stromal cells were treated with E +/- P +/- monocyte conditioned medium; U937 were treated +/- T-HESC conditioned medium. Gene expression in response to treatment was examined by DNA microarray. Bidirectional communication, as demonstrated by changes in gene expression, clearly occurred between U937 monocytes and T-HESC. |
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Authors:
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Olga Klinkova; Keith A Hansen; Emily Winterton; Connie J Mark; Kathleen M Eyster |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2009-10-20 |
Journal Detail:
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Title: Reproductive sciences (Thousand Oaks, Calif.) Volume: 17 ISSN: 1933-7205 ISO Abbreviation: Reprod Sci Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-04 Completed Date: 2010-04-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101291249 Medline TA: Reprod Sci Country: United States |
Other Details:
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Languages: eng Pagination: 125-36 Citation Subset: IM |
Affiliation:
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Division of Basic Biomedical Sciences, Sanford School of Medicine of the University of South Dakota, Vermillion, South Dakota 57069, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Communication
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drug effects,
physiology* Cell Line, Transformed Culture Media, Conditioned / pharmacology Endometriosis / pathology*, physiopathology Endometrium / cytology* Estradiol / pharmacology Female Humans Monocytes / cytology* Oligonucleotide Array Sequence Analysis Prolactin / genetics Reverse Transcriptase Polymerase Chain Reaction Stromal Cells / cytology* Telomerase / genetics U937 Cells |
| Grant Support | |
ID/Acronym/Agency:
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2 P20 RR016479/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Culture Media, Conditioned; 50-28-2/Estradiol; 9002-62-4/Prolactin; EC 2.7.7.49/Telomerase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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