| A Two-Stage Matched Case-Control Study on Multiple Hypertensive Candidate Genes in Han Chinese. | |
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MedLine Citation:
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PMID: 22534794 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BackgroundHypertension affects about 1/3 of adults worldwide, ~3.8 million in Taiwan, 160 million in China, and 1 billion worldwide. It is a major risk factor leading to stroke, cardiovascular disease, and end-stage renal disease. In each year, more than 13.5 million deaths are due to hypertension-related diseases worldwide.MethodsWe performed a two-stage association study of hypertension using genotype data of single-nucleotide polymorphisms (SNPs) from 992 young-onset hypertensive cases and 992 matched controls of Han Chinese in Taiwan. A total of 238 SNPs of 36 highly replicated hypertension candidate genes with functional importance were investigated. Association analysis was carried out using conditional logistic regression.ResultsWe identified two SNPs that were strongly associated with hypertension in both the first and the second stages. The first SNP (rs2301339) is located at guanine nucleotide-binding protein β3 subunit (GNB3) and the other one (rs17254521) is located at insulin receptor (INSR).ConclusionsSNP rs2301339 is perfectly linked in linkage disequilibrium (LD) with C825T (rs5443) which has been associated with hypertension in Caucasian, but inconsistent in Asian populations. However, we found that in our sample this SNP has an opposite effect with the previous findings. In summary, this study identified one novel SNP in GNB3 and one novel SNP in INSR that are strongly associated with young-onset hypertension. Due to relatively small sample size, the results should still be interpreted with caution and need to be replicated in other studies.American Journal of Hypertension 2012; doi:10.1038/ajh.2012.44. |
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Authors:
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Tai-Yue Kuo; Mei-Jyh Kang; Jaw-Wen Chen; Hung-Yun Ho; Chih-Tai Ting; Tsung-Hsien Lin; Sheng-Hsiung Sheu; Wei-Chuan Tsai; Jyh-Hong Chen; Hsin-Bang Leu; Wei-Hsian Yin; Ting-Yu Chiu; Chin-Iuan Chen; Shing-Jong Lin; Wen-Harn Pan |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-4-26 |
Journal Detail:
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Title: American journal of hypertension Volume: - ISSN: 1941-7225 ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-4-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8803676 Medline TA: Am J Hypertens Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. |
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