Document Detail


Two Protocols to Measure Mitochondrial Capacity in Women and Adolescent Girls: A 31P-MRS Preliminary Study.
MedLine Citation:
PMID:  24893379     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The phosphocreatine (PCr) recovery time constant (τ) following exercise provides a measure of mitochondrial oxidative capacity. The purpose of this investigation was to use 2 different protocols to determine τ in adolescent females. 31P-MR spectra were collected during 2 exercise tests in 6 adolescent girls (13.8 ± 0.3 y) and 7 women (23.2 ± 3.4 y). The first test consisted of 23 repeated 4 seconds maximal isometric calf contractions separated by 12-second recovery; PCr recovery between the final 18 contractions was used to calculate τ. The second test was a sustained 20-second maximal contraction; recovery was fitted with an exponential function to measure τ. PCr τ did not significantly differ between groups: (gated exercise: 4 girls: 16 ± 5 s, 7 women: 17 ± 5 s, p; sustained exercise: 6 girls: 19 ± 6 s, 7 women: 19 ± 4 s). Bland-Altman analysis demonstrated a close agreement between sustained and gated exercise. Both gated and sustained exercise appear feasible in a pediatric population, and offer a noninvasive evaluation of mitochondrial oxidative capacity.
Authors:
Rebecca Jane Willcocks; Jon Fulford; Alan Robert Barker; Neil Armstrong; Craig Anthony Williams
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric exercise science     Volume:  26     ISSN:  1543-2920     ISO Abbreviation:  Pediatr Exerc Sci     Publication Date:  2014 May 
Date Detail:
Created Date:  2014-06-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8909729     Medline TA:  Pediatr Exerc Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  210-7     Citation Subset:  IM    
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