Document Detail


Two DNA translocases synergistically affect chromosome dimer resolution in Bacillus subtilis.
MedLine Citation:
PMID:  21239579     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In Bacillus subtilis, chromosome dimers that block complete segregation of sister chromosomes arise in about 15% of exponentially growing cells. Two dedicated recombinases, RipX and CodV, catalyze the resolution of dimers by site-specific recombination at the dif site, which is located close to the terminus region on the chromosome. We show that the two DNA translocases in B. subtilis, SftA and SpoIIIE, synergistically affect dimer resolution, presumably by positioning the dif sites in close proximity, before or after completion of cell division, respectively. Furthermore, we observed that both recombinases, RipX and CodV, assemble on the chromosome at the dif site throughout the cell cycle. The preassembly of recombinases probably ensures that dimer resolution can occur rapidly within a short time window around cell division.
Authors:
Christine Kaimer; Katrin Schenk; Peter L Graumann
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-01-14
Journal Detail:
Title:  Journal of bacteriology     Volume:  193     ISSN:  1098-5530     ISO Abbreviation:  J. Bacteriol.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-25     Completed Date:  2011-04-18     Revised Date:  2013-07-02    
Medline Journal Info:
Nlm Unique ID:  2985120R     Medline TA:  J Bacteriol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1334-40     Citation Subset:  IM    
Affiliation:
Mikrobiologie, Fachbereich für Biologie, Universität Freiburg, Schänzle Straße 1, 79104 Freiburg, Germany.
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MeSH Terms
Descriptor/Qualifier:
Bacillus subtilis / cytology,  enzymology*,  genetics,  metabolism*
Chromosome Segregation*
Chromosomes, Bacterial / metabolism*
DNA, Bacterial / metabolism*
Phosphoric Monoester Hydrolases / metabolism*
Chemical
Reg. No./Substance:
0/DNA, Bacterial; EC 3.1.3.-/Phosphoric Monoester Hydrolases
Comments/Corrections

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