Document Detail

Two Cases of Transfusion-Transmitted Anaplasma phagocytophilum.
MedLine Citation:
PMID:  22431531     Owner:  NLM     Status:  In-Data-Review    
Anaplasma phagocytophilum, the causative agent of human granulocytic anaplasmosis, is an obligate intracellular bacterium most commonly acquired from tick bites. High seroprevalence rates in endemic regions suggest that transfusion transmission of A phagocytophilum would be a common event; however, only 2 cases have previously been reported. The exact cause of this discrepancy is not known. Whole blood leukocyte-reduction methods used by many blood centers are thought to reduce the risk of transfusion transmission of many pathogens, including A phagocytophilum. We report 2 additional cases of transfusion-transmitted A phagocytophilum in which leukocyte reduction of all transfused units failed to prevent microbial transmission.
Kyle Annen; Kenneth Friedman; Camellia Eshoa; Mary Horowitz; Jerome Gottschall; Todd Straus
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of clinical pathology     Volume:  137     ISSN:  1943-7722     ISO Abbreviation:  Am. J. Clin. Pathol.     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-03-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370470     Medline TA:  Am J Clin Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  562-5     Citation Subset:  AIM; IM    
BloodCenter of Wisconsin, 638 18th St, Milwaukee, WI 53233.
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