| Two Babinski signs in seropositive (HAM) and seronegative tropical spastic paraparesis. | |
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MedLine Citation:
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PMID: 18949264 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Tropical spastic paraparesis (TSP) may or may not be associated to HTLV-I antibodies and is usually characterized by clinical and pathological spinal cord abnormalities at thoracic levels. We present here five Brazilian patients who had typical chronic idiopathic spastic paraparesis; two of them were HTLV-I seropositive (HAM) and three HTLV-I seronegative (TSP) -associated-myelopathy. Three out of these five patients also displayed clinical supraspinal involvement, indeed, platysma muscle hypotrophy or atrophy (the Babinski plus sign). These findings support the view that clinical involvement in HAM and TSP is wider than the spinal cord abnormalities usually considered. Possible non-infectious co-factors (e.g., mycotoxins) may be involved in disease pathogenesis in a multistep process of viruses, toxins and environment which may account for serological differences found in this group of patients. |
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Authors:
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Fidias E Leon-Sarmiento; Andres Calderon; Hernan G Hernandez |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Arquivos de neuro-psiquiatria Volume: 66 ISSN: 1678-4227 ISO Abbreviation: Arq Neuropsiquiatr Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-10-24 Completed Date: 2009-08-19 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0125444 Medline TA: Arq Neuropsiquiatr Country: Brazil |
Other Details:
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Languages: eng Pagination: 695-7 Citation Subset: IM |
Affiliation:
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Unit of Movement Disorders and Neuromagnetismo, Neurology Section, Fundacion Santa Fe, Bogota, Colombia. feleones@gmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Chronic Disease Female HTLV-I Antibodies / blood Human T-lymphotropic virus 1 / immunology Humans Male Middle Aged Paraparesis, Spastic / complications*, diagnosis Paraparesis, Tropical Spastic / complications*, diagnosis Reflex, Babinski / etiology* |
| Chemical | |
Reg. No./Substance:
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0/HTLV-I Antibodies |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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