| Twitch potentiation and caffeine contractures in isolated rat soleus muscle. | |
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MedLine Citation:
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PMID: 6133688 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. Electrically-evoked twitch and tetanic tension were measured in isolated rat soleus muscle after exposure to caffeine. 2. Between 0.01 and 2.5 mM caffeine twitch tension was potentiated, reaching a peak of 150% of Resting Tension at 0.5 mM. 3. Biphasic Tension development with relaxation was observed at 2.5 mM caffeine with maximal contractures (110% tetanic tension) occurring at 20 mM. 4. Creatine phosphate and ATP stores were maintained throughout the period of tension development and relaxation. 5. In contrast with amphibian muscle, the isolated soleus is very sensitive to low doses of caffeine and produces biphasic caffeine contractures which relax in the presence of caffeine. |
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Authors:
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R J Connett; L M Ugol; M J Hammack; E T Hays |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology Volume: 74 ISSN: 0742-8413 ISO Abbreviation: Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. Publication Date: 1983 |
Date Detail:
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Created Date: 1983-07-08 Completed Date: 1983-07-08 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8310013 Medline TA: Comp Biochem Physiol C Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 349-54 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Triphosphate
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metabolism Animals Caffeine / pharmacology* Electric Stimulation Male Muscle Contraction / drug effects* Muscles / physiology* Phosphocreatine / metabolism Rats Rats, Inbred Strains Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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5K04AM00155/AM/NIADDK NIH HHS; AM22124/AM/NIADDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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56-65-5/Adenosine Triphosphate; 58-08-2/Caffeine; 67-07-2/Phosphocreatine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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