Document Detail


Twist factor regulation of non-cardiomyocyte cell lineages in the developing heart.
MedLine Citation:
PMID:  22516205     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The heart is a complex organ that is composed of numerous cell types, which must integrate their programs for proper specification, differentiation and cardiac morphogenesis. During cardiogenesis members of the Twist-family of basic helix-loop-helix (bHLH) transcription factors play distinct roles within cardiac lineages such as the endocardium and extra-cardiac lineages such as the cardiac neural crest (cNCC) and epicardium. While the study of these cell populations is often eclipsed by that of cardiomyocytes, the contributions of non-cardiomyocytes to development and disease are increasingly being appreciated as both dynamic and essential. This review summarizes what is known regarding Twist-family bHLH function in extra-cardiac cell populations and the endocardium, with a focus on regulatory mechanisms, downstream targets, and expression profiles. Improving our understanding of the molecular pathways that Twist-family bHLH factors mediate in these lineages will be necessary to ascertain how their dysfunction leads to congenital disease and adult pathologies such as myocardial infarctions and cardiac fibroblast induced fibrosis. Indeed, this knowledge will prove to be critical to clinicians seeking to improve current treatments.
Authors:
Nathan J VanDusen; Anthony B Firulli
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2012-04-17
Journal Detail:
Title:  Differentiation; research in biological diversity     Volume:  84     ISSN:  1432-0436     ISO Abbreviation:  Differentiation     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-07-03     Completed Date:  2012-11-12     Revised Date:  2014-09-12    
Medline Journal Info:
Nlm Unique ID:  0401650     Medline TA:  Differentiation     Country:  England    
Other Details:
Languages:  eng     Pagination:  79-88     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 International Society of Differentiation. Published by Elsevier B.V. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Differentiation
Cell Lineage
Embryonic Stem Cells / cytology,  metabolism
Endocardium / cytology,  embryology*
Endothelial Cells / cytology,  metabolism
Fibroblasts / cytology,  metabolism
Gene Expression Regulation, Developmental
Heart Defects, Congenital / metabolism
Humans
Mice
Myocardium / cytology*
Neural Crest / cytology,  embryology*
Pericardium / cytology,  embryology*
Transcription, Genetic
Twist Transcription Factor / metabolism*
Grant Support
ID/Acronym/Agency:
1P01HL085098-05/HL/NHLBI NIH HHS; P01 HL085098/HL/NHLBI NIH HHS; P01 HL085098-05/HL/NHLBI NIH HHS; R01 AR061392/AR/NIAMS NIH HHS; R01 AR061392-01/AR/NIAMS NIH HHS; R01 HL061677/HL/NHLBI NIH HHS; R01 HL061677-12/HL/NHLBI NIH HHS; R01HL061677-12/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Twist Transcription Factor
Comments/Corrections

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