Document Detail

Twist factor regulation of non-cardiomyocyte cell lineages in the developing heart.
MedLine Citation:
PMID:  22516205     Owner:  NLM     Status:  MEDLINE    
The heart is a complex organ that is composed of numerous cell types, which must integrate their programs for proper specification, differentiation and cardiac morphogenesis. During cardiogenesis members of the Twist-family of basic helix-loop-helix (bHLH) transcription factors play distinct roles within cardiac lineages such as the endocardium and extra-cardiac lineages such as the cardiac neural crest (cNCC) and epicardium. While the study of these cell populations is often eclipsed by that of cardiomyocytes, the contributions of non-cardiomyocytes to development and disease are increasingly being appreciated as both dynamic and essential. This review summarizes what is known regarding Twist-family bHLH function in extra-cardiac cell populations and the endocardium, with a focus on regulatory mechanisms, downstream targets, and expression profiles. Improving our understanding of the molecular pathways that Twist-family bHLH factors mediate in these lineages will be necessary to ascertain how their dysfunction leads to congenital disease and adult pathologies such as myocardial infarctions and cardiac fibroblast induced fibrosis. Indeed, this knowledge will prove to be critical to clinicians seeking to improve current treatments.
Nathan J VanDusen; Anthony B Firulli
Related Documents :
8416075 - Respiratory sinus arrhythmia, cardiac vagal tone, and respiration: within- and between-...
882485 - Polyradiculoneuritis and mycoplasma pneumoniae infection.
21747665 - Syncope in cardiac amyloidosis and chronic ischemic heart disease: a case report.
10494945 - Transient vertical diplopia and silent sinus disorder.
3203035 - Differential sensitivity of radionuclide ventriculography for the detection of anterior...
11349145 - Simultaneous rupture along two conjugate planes of the wharton basin earthquake.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2012-04-17
Journal Detail:
Title:  Differentiation; research in biological diversity     Volume:  84     ISSN:  1432-0436     ISO Abbreviation:  Differentiation     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-07-03     Completed Date:  2012-11-12     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  0401650     Medline TA:  Differentiation     Country:  England    
Other Details:
Languages:  eng     Pagination:  79-88     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 International Society of Differentiation. Published by Elsevier B.V. All rights reserved.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cell Differentiation
Cell Lineage
Embryonic Stem Cells / cytology,  metabolism
Endocardium / cytology,  embryology*
Endothelial Cells / cytology,  metabolism
Fibroblasts / cytology,  metabolism
Gene Expression Regulation, Developmental
Heart Defects, Congenital / metabolism
Myocardium / cytology*
Neural Crest / cytology,  embryology*
Pericardium / cytology,  embryology*
Transcription, Genetic
Twist Transcription Factor / metabolism*
Grant Support
1P01HL085098-05/HL/NHLBI NIH HHS; P01 HL085098/HL/NHLBI NIH HHS; P01 HL085098-05/HL/NHLBI NIH HHS; R01 AR061392/AR/NIAMS NIH HHS; R01 AR061392-01/AR/NIAMS NIH HHS; R01 HL061677/HL/NHLBI NIH HHS; R01 HL061677-12/HL/NHLBI NIH HHS; R01HL061677-12/HL/NHLBI NIH HHS
Reg. No./Substance:
0/Twist Transcription Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Sapovirus outbreaks in long-term care facilities, Oregon and Minnesota, USA, 2002-2009.
Next Document:  Formation of dioxins during exposure of pesticide formulations to sunlight.